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Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus

To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation betw...

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Autores principales: Robles-Cervantes, J. A., Ramos-Zavala, M. G., González-Ortiz, M., Martínez-Abundis, E., Valencia-Sandoval, C., Torres-Chávez, A., Espinel-Bermúdez, C., Santiago-Hernández, N. J., Hernández-González, S. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246727/
https://www.ncbi.nlm.nih.gov/pubmed/22216028
http://dx.doi.org/10.1155/2011/107904
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author Robles-Cervantes, J. A.
Ramos-Zavala, M. G.
González-Ortiz, M.
Martínez-Abundis, E.
Valencia-Sandoval, C.
Torres-Chávez, A.
Espinel-Bermúdez, C.
Santiago-Hernández, N. J.
Hernández-González, S. O.
author_facet Robles-Cervantes, J. A.
Ramos-Zavala, M. G.
González-Ortiz, M.
Martínez-Abundis, E.
Valencia-Sandoval, C.
Torres-Chávez, A.
Espinel-Bermúdez, C.
Santiago-Hernández, N. J.
Hernández-González, S. O.
author_sort Robles-Cervantes, J. A.
collection PubMed
description To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation between uric acid with male gender r = 0.710 (P = 0.001). Also correlation between uric acid and total insulin secretion was positive r = 0.295 (P = 0.049). As well as a positive correlation adjusted for body mass index was demonstrated for the first, second, and total phases of insulin secretion, respectively, r = 0.438 (P = 0.022), r = 0.433 (P = 0.022), and r = 0.439 (P = 0.024). Serum concentration of uric acid showed a positive relationship with the total phase of insulin secretion; even in states prior to hyperuricemia, uric acid can play an important role in the function of the beta cell in patients with DM2.
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spelling pubmed-32467272012-01-03 Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus Robles-Cervantes, J. A. Ramos-Zavala, M. G. González-Ortiz, M. Martínez-Abundis, E. Valencia-Sandoval, C. Torres-Chávez, A. Espinel-Bermúdez, C. Santiago-Hernández, N. J. Hernández-González, S. O. Int J Endocrinol Clinical Study To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation between uric acid with male gender r = 0.710 (P = 0.001). Also correlation between uric acid and total insulin secretion was positive r = 0.295 (P = 0.049). As well as a positive correlation adjusted for body mass index was demonstrated for the first, second, and total phases of insulin secretion, respectively, r = 0.438 (P = 0.022), r = 0.433 (P = 0.022), and r = 0.439 (P = 0.024). Serum concentration of uric acid showed a positive relationship with the total phase of insulin secretion; even in states prior to hyperuricemia, uric acid can play an important role in the function of the beta cell in patients with DM2. Hindawi Publishing Corporation 2011 2011-12-14 /pmc/articles/PMC3246727/ /pubmed/22216028 http://dx.doi.org/10.1155/2011/107904 Text en Copyright © 2011 J. A. Robles-Cervantes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Robles-Cervantes, J. A.
Ramos-Zavala, M. G.
González-Ortiz, M.
Martínez-Abundis, E.
Valencia-Sandoval, C.
Torres-Chávez, A.
Espinel-Bermúdez, C.
Santiago-Hernández, N. J.
Hernández-González, S. O.
Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
title Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
title_full Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
title_fullStr Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
title_full_unstemmed Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
title_short Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
title_sort relationship between serum concentration of uric acid and insulin secretion among adults with type 2 diabetes mellitus
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246727/
https://www.ncbi.nlm.nih.gov/pubmed/22216028
http://dx.doi.org/10.1155/2011/107904
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