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Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus
To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation betw...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246727/ https://www.ncbi.nlm.nih.gov/pubmed/22216028 http://dx.doi.org/10.1155/2011/107904 |
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author | Robles-Cervantes, J. A. Ramos-Zavala, M. G. González-Ortiz, M. Martínez-Abundis, E. Valencia-Sandoval, C. Torres-Chávez, A. Espinel-Bermúdez, C. Santiago-Hernández, N. J. Hernández-González, S. O. |
author_facet | Robles-Cervantes, J. A. Ramos-Zavala, M. G. González-Ortiz, M. Martínez-Abundis, E. Valencia-Sandoval, C. Torres-Chávez, A. Espinel-Bermúdez, C. Santiago-Hernández, N. J. Hernández-González, S. O. |
author_sort | Robles-Cervantes, J. A. |
collection | PubMed |
description | To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation between uric acid with male gender r = 0.710 (P = 0.001). Also correlation between uric acid and total insulin secretion was positive r = 0.295 (P = 0.049). As well as a positive correlation adjusted for body mass index was demonstrated for the first, second, and total phases of insulin secretion, respectively, r = 0.438 (P = 0.022), r = 0.433 (P = 0.022), and r = 0.439 (P = 0.024). Serum concentration of uric acid showed a positive relationship with the total phase of insulin secretion; even in states prior to hyperuricemia, uric acid can play an important role in the function of the beta cell in patients with DM2. |
format | Online Article Text |
id | pubmed-3246727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32467272012-01-03 Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus Robles-Cervantes, J. A. Ramos-Zavala, M. G. González-Ortiz, M. Martínez-Abundis, E. Valencia-Sandoval, C. Torres-Chávez, A. Espinel-Bermúdez, C. Santiago-Hernández, N. J. Hernández-González, S. O. Int J Endocrinol Clinical Study To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation between uric acid with male gender r = 0.710 (P = 0.001). Also correlation between uric acid and total insulin secretion was positive r = 0.295 (P = 0.049). As well as a positive correlation adjusted for body mass index was demonstrated for the first, second, and total phases of insulin secretion, respectively, r = 0.438 (P = 0.022), r = 0.433 (P = 0.022), and r = 0.439 (P = 0.024). Serum concentration of uric acid showed a positive relationship with the total phase of insulin secretion; even in states prior to hyperuricemia, uric acid can play an important role in the function of the beta cell in patients with DM2. Hindawi Publishing Corporation 2011 2011-12-14 /pmc/articles/PMC3246727/ /pubmed/22216028 http://dx.doi.org/10.1155/2011/107904 Text en Copyright © 2011 J. A. Robles-Cervantes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Robles-Cervantes, J. A. Ramos-Zavala, M. G. González-Ortiz, M. Martínez-Abundis, E. Valencia-Sandoval, C. Torres-Chávez, A. Espinel-Bermúdez, C. Santiago-Hernández, N. J. Hernández-González, S. O. Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus |
title | Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus |
title_full | Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus |
title_fullStr | Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus |
title_full_unstemmed | Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus |
title_short | Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus |
title_sort | relationship between serum concentration of uric acid and insulin secretion among adults with type 2 diabetes mellitus |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246727/ https://www.ncbi.nlm.nih.gov/pubmed/22216028 http://dx.doi.org/10.1155/2011/107904 |
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