Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in...

Descripción completa

Detalles Bibliográficos
Autores principales: Sideridou, Maria, Zakopoulou, Roubini, Evangelou, Konstantinos, Liontos, Michalis, Kotsinas, Athanassios, Rampakakis, Emmanouil, Gagos, Sarantis, Kahata, Kaoru, Grabusic, Kristina, Gkouskou, Kalliopi, Trougakos, Ioannis P., Kolettas, Evangelos, Georgakilas, Alexandros G., Volarevic, Sinisa, Eliopoulos, Aristides G., Zannis-Hadjopoulos, Maria, Moustakas, Aristidis, Gorgoulis, Vassilis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246883/
https://www.ncbi.nlm.nih.gov/pubmed/22201124
http://dx.doi.org/10.1083/jcb.201108121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246883/
https://www.ncbi.nlm.nih.gov/pubmed/22201124
http://dx.doi.org/10.1083/jcb.201108121

Ejemplares similares