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Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

BACKGROUND: Hemostasis is a critical and active function of the blood mediated by platelets. Therefore, the prevention of pathological platelet aggregation is of great importance as well as of pharmaceutical and medical interest. Endogenous platelet inhibition is predominantly based on cyclic nucleo...

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Detalles Bibliográficos
Autores principales:	Wangorsch, Gaby, Butt, Elke, Mark, Regina, Hubertus, Katharina, Geiger, Jörg, Dandekar, Thomas, Dittrich, Marcus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247139/ https://www.ncbi.nlm.nih.gov/pubmed/22034949 http://dx.doi.org/10.1186/1752-0509-5-178

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