An association study of the COL1A1 gene and high myopia in a Han Chinese population

PURPOSE: Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population. ME...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Dingding, Shi, Yi, Gong, Bo, He, Fei, Lu, Fang, Lin, He, Wu, Zhengzheng, Cheng, Jing, Chen, Bin, Liao, Shihuang, Ma, Shi, Hu, Jianbin, Yang, Zhenglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247168/
https://www.ncbi.nlm.nih.gov/pubmed/22219633
Descripción
Sumario:PURPOSE: Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population. METHODS: High myopia is defined by a spherical equivalent of less than or equal to −6.00 diopter sphere and an axial length longer than or equal to 26.0 mm in the affected eye. We genotyped rs2075555 and rs2269336 SNPs in COL1A1 in a Ha n Chinese group composed of 697 high myopia patients and 762 normal controls. RESULTS: Neither of the two SNPs showed significant association with high myopia (p(allelic)=0.252 for rs2075555, and p(allelic)=0.699 for rs2269336). CONCLUSIONS: Our study revealed that SNPs in COL1A1 are not significantly associated with high myopia in the Han Chinese population.

Ejemplares similares