An association study of the COL1A1 gene and high myopia in a Han Chinese population

PURPOSE: Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population. ME...

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Autores principales: Zhang, Dingding, Shi, Yi, Gong, Bo, He, Fei, Lu, Fang, Lin, He, Wu, Zhengzheng, Cheng, Jing, Chen, Bin, Liao, Shihuang, Ma, Shi, Hu, Jianbin, Yang, Zhenglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247168/
https://www.ncbi.nlm.nih.gov/pubmed/22219633
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author Zhang, Dingding
Shi, Yi
Gong, Bo
He, Fei
Lu, Fang
Lin, He
Wu, Zhengzheng
Cheng, Jing
Chen, Bin
Liao, Shihuang
Ma, Shi
Hu, Jianbin
Yang, Zhenglin
author_facet Zhang, Dingding
Shi, Yi
Gong, Bo
He, Fei
Lu, Fang
Lin, He
Wu, Zhengzheng
Cheng, Jing
Chen, Bin
Liao, Shihuang
Ma, Shi
Hu, Jianbin
Yang, Zhenglin
author_sort Zhang, Dingding
collection PubMed
description PURPOSE: Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population. METHODS: High myopia is defined by a spherical equivalent of less than or equal to −6.00 diopter sphere and an axial length longer than or equal to 26.0 mm in the affected eye. We genotyped rs2075555 and rs2269336 SNPs in COL1A1 in a Ha n Chinese group composed of 697 high myopia patients and 762 normal controls. RESULTS: Neither of the two SNPs showed significant association with high myopia (p(allelic)=0.252 for rs2075555, and p(allelic)=0.699 for rs2269336). CONCLUSIONS: Our study revealed that SNPs in COL1A1 are not significantly associated with high myopia in the Han Chinese population.
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spelling pubmed-32471682012-01-04 An association study of the COL1A1 gene and high myopia in a Han Chinese population Zhang, Dingding Shi, Yi Gong, Bo He, Fei Lu, Fang Lin, He Wu, Zhengzheng Cheng, Jing Chen, Bin Liao, Shihuang Ma, Shi Hu, Jianbin Yang, Zhenglin Mol Vis Research Article PURPOSE: Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population. METHODS: High myopia is defined by a spherical equivalent of less than or equal to −6.00 diopter sphere and an axial length longer than or equal to 26.0 mm in the affected eye. We genotyped rs2075555 and rs2269336 SNPs in COL1A1 in a Ha n Chinese group composed of 697 high myopia patients and 762 normal controls. RESULTS: Neither of the two SNPs showed significant association with high myopia (p(allelic)=0.252 for rs2075555, and p(allelic)=0.699 for rs2269336). CONCLUSIONS: Our study revealed that SNPs in COL1A1 are not significantly associated with high myopia in the Han Chinese population. Molecular Vision 2011-12-24 /pmc/articles/PMC3247168/ /pubmed/22219633 Text en Copyright © 2011 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Dingding
Shi, Yi
Gong, Bo
He, Fei
Lu, Fang
Lin, He
Wu, Zhengzheng
Cheng, Jing
Chen, Bin
Liao, Shihuang
Ma, Shi
Hu, Jianbin
Yang, Zhenglin
An association study of the COL1A1 gene and high myopia in a Han Chinese population
title An association study of the COL1A1 gene and high myopia in a Han Chinese population
title_full An association study of the COL1A1 gene and high myopia in a Han Chinese population
title_fullStr An association study of the COL1A1 gene and high myopia in a Han Chinese population
title_full_unstemmed An association study of the COL1A1 gene and high myopia in a Han Chinese population
title_short An association study of the COL1A1 gene and high myopia in a Han Chinese population
title_sort association study of the col1a1 gene and high myopia in a han chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247168/
https://www.ncbi.nlm.nih.gov/pubmed/22219633
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