Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects

BACKGROUND: Previous studies have demonstrated that QX-314, an intracellular sodium channel blocker, can enter into nociceptors through capsaicin-activated TRPV1 or permeation of the membrane by chemical enhancers to produce a sensory-selective blockade. However, the obvious side effects of these co...

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Detalles Bibliográficos
Autores principales: Liu, He, Zhang, Hong-Xing, Hou, Hui-Yan, Lu, Xian-Fu, Wei, Jing-Qiu, Wang, Chun-Guang, Zhang, Li-Cai, Zeng, Yin-Ming, Wu, Yong-Ping, Cao, Jun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247264/
https://www.ncbi.nlm.nih.gov/pubmed/22216270
http://dx.doi.org/10.1371/journal.pone.0029395

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