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Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing
The continued addition of new neurons to mature olfactory circuits represents a remarkable mode of cellular and structural brain plasticity. However, the anatomical configuration of newly established circuits, the types and numbers of neurons that form new synaptic connections, and the effect of sen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247270/ https://www.ncbi.nlm.nih.gov/pubmed/22216277 http://dx.doi.org/10.1371/journal.pone.0029423 |
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author | Arenkiel, Benjamin R. Hasegawa, Hiroshi Yi, Jason J. Larsen, Rylan S. Wallace, Michael L. Philpot, Benjamin D. Wang, Fan Ehlers, Michael D. |
author_facet | Arenkiel, Benjamin R. Hasegawa, Hiroshi Yi, Jason J. Larsen, Rylan S. Wallace, Michael L. Philpot, Benjamin D. Wang, Fan Ehlers, Michael D. |
author_sort | Arenkiel, Benjamin R. |
collection | PubMed |
description | The continued addition of new neurons to mature olfactory circuits represents a remarkable mode of cellular and structural brain plasticity. However, the anatomical configuration of newly established circuits, the types and numbers of neurons that form new synaptic connections, and the effect of sensory experience on synaptic connectivity in the olfactory bulb remain poorly understood. Using in vivo electroporation and monosynaptic tracing, we show that postnatal-born granule cells form synaptic connections with centrifugal inputs and mitral/tufted cells in the mouse olfactory bulb. In addition, newly born granule cells receive extensive input from local inhibitory short axon cells, a poorly understood cell population. The connectivity of short axon cells shows clustered organization, and their synaptic input onto newborn granule cells dramatically and selectively expands with odor stimulation. Our findings suggest that sensory experience promotes the synaptic integration of new neurons into cell type-specific olfactory circuits. |
format | Online Article Text |
id | pubmed-3247270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32472702012-01-03 Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing Arenkiel, Benjamin R. Hasegawa, Hiroshi Yi, Jason J. Larsen, Rylan S. Wallace, Michael L. Philpot, Benjamin D. Wang, Fan Ehlers, Michael D. PLoS One Research Article The continued addition of new neurons to mature olfactory circuits represents a remarkable mode of cellular and structural brain plasticity. However, the anatomical configuration of newly established circuits, the types and numbers of neurons that form new synaptic connections, and the effect of sensory experience on synaptic connectivity in the olfactory bulb remain poorly understood. Using in vivo electroporation and monosynaptic tracing, we show that postnatal-born granule cells form synaptic connections with centrifugal inputs and mitral/tufted cells in the mouse olfactory bulb. In addition, newly born granule cells receive extensive input from local inhibitory short axon cells, a poorly understood cell population. The connectivity of short axon cells shows clustered organization, and their synaptic input onto newborn granule cells dramatically and selectively expands with odor stimulation. Our findings suggest that sensory experience promotes the synaptic integration of new neurons into cell type-specific olfactory circuits. Public Library of Science 2011-12-28 /pmc/articles/PMC3247270/ /pubmed/22216277 http://dx.doi.org/10.1371/journal.pone.0029423 Text en Arenkiel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Arenkiel, Benjamin R. Hasegawa, Hiroshi Yi, Jason J. Larsen, Rylan S. Wallace, Michael L. Philpot, Benjamin D. Wang, Fan Ehlers, Michael D. Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing |
title | Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing |
title_full | Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing |
title_fullStr | Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing |
title_full_unstemmed | Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing |
title_short | Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing |
title_sort | activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247270/ https://www.ncbi.nlm.nih.gov/pubmed/22216277 http://dx.doi.org/10.1371/journal.pone.0029423 |
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