Thailandepsin A

Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl]-5-hy­droxy-20-[2-(meth­yl­sulfan­yl)eth­yl]-2-oxa-11,12-dithia-7,19,22-triaza­bicyclo­[7.7.6]docosa-15-ene-3,8,18,21-tetra­one], C(23)H(37)N(3)O(6)S(3), is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl­ase inhibitory activity and broad-spectrum anti­proliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intra­molecular N—H⋯O and N—H⋯S hydrogen bonds occur. Inter­molecular N—H⋯O and O—H⋯O hydrogen bonds are observed in the crystal structure.