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tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate
The title compound, C(24)H(42)N(2)O(7), is a chiral lactam-constrained amino acid with a six-membered ring backbone and isopropyl and tert-butyl ester side chains. The conformation of the six-membered ring can be described as a half chair, with two CH(2) C atoms lying 0.443 (1) and −0.310 (1) Å out...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247449/ https://www.ncbi.nlm.nih.gov/pubmed/22220067 http://dx.doi.org/10.1107/S1600536811043212 |
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author | Kangas, Michael J. Fronczek, Frank R. Watkins, Steven F. |
author_facet | Kangas, Michael J. Fronczek, Frank R. Watkins, Steven F. |
author_sort | Kangas, Michael J. |
collection | PubMed |
description | The title compound, C(24)H(42)N(2)O(7), is a chiral lactam-constrained amino acid with a six-membered ring backbone and isopropyl and tert-butyl ester side chains. The conformation of the six-membered ring can be described as a half chair, with two CH(2) C atoms lying 0.443 (1) and −0.310 (1) Å out of the best plane of the other four atoms (mean deviation = 0.042 Å). Both N atoms are sp (2) hybridized, lying 0.0413 (9) and 0.067 (1) Å out of the planes defined by the three C atoms bonded to them. The absolute configuration was determined, based on resonant scattering of light atoms in Cu Kα radiation. |
format | Online Article Text |
id | pubmed-3247449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32474492012-01-04 tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate Kangas, Michael J. Fronczek, Frank R. Watkins, Steven F. Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(24)H(42)N(2)O(7), is a chiral lactam-constrained amino acid with a six-membered ring backbone and isopropyl and tert-butyl ester side chains. The conformation of the six-membered ring can be described as a half chair, with two CH(2) C atoms lying 0.443 (1) and −0.310 (1) Å out of the best plane of the other four atoms (mean deviation = 0.042 Å). Both N atoms are sp (2) hybridized, lying 0.0413 (9) and 0.067 (1) Å out of the planes defined by the three C atoms bonded to them. The absolute configuration was determined, based on resonant scattering of light atoms in Cu Kα radiation. International Union of Crystallography 2011-10-29 /pmc/articles/PMC3247449/ /pubmed/22220067 http://dx.doi.org/10.1107/S1600536811043212 Text en © Kangas et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Kangas, Michael J. Fronczek, Frank R. Watkins, Steven F. tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate |
title |
tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate
|
title_full |
tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate
|
title_fullStr |
tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate
|
title_full_unstemmed |
tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate
|
title_short |
tert-Butyl (2S)-2-{3-[(R)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate
|
title_sort | tert-butyl (2s)-2-{3-[(r)-bis(tert-butoxycarbonyl)amino]-2-oxopiperidin-1-yl}-3-methylbutanoate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247449/ https://www.ncbi.nlm.nih.gov/pubmed/22220067 http://dx.doi.org/10.1107/S1600536811043212 |
work_keys_str_mv | AT kangasmichaelj tertbutyl2s23rbistertbutoxycarbonylamino2oxopiperidin1yl3methylbutanoate AT fronczekfrankr tertbutyl2s23rbistertbutoxycarbonylamino2oxopiperidin1yl3methylbutanoate AT watkinsstevenf tertbutyl2s23rbistertbutoxycarbonylamino2oxopiperidin1yl3methylbutanoate |