Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions

Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three dif...

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Detalles Bibliográficos
Autores principales: Himmelhaus, Michael, Krishnamoorthy, Sivashankar, Francois, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247756/
https://www.ncbi.nlm.nih.gov/pubmed/22219711
http://dx.doi.org/10.3390/s100606257
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author Himmelhaus, Michael
Krishnamoorthy, Sivashankar
Francois, Alexandre
author_facet Himmelhaus, Michael
Krishnamoorthy, Sivashankar
Francois, Alexandre
author_sort Himmelhaus, Michael
collection PubMed
description Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study.
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spelling pubmed-32477562012-01-04 Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions Himmelhaus, Michael Krishnamoorthy, Sivashankar Francois, Alexandre Sensors (Basel) Article Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study. Molecular Diversity Preservation International (MDPI) 2010-06-22 /pmc/articles/PMC3247756/ /pubmed/22219711 http://dx.doi.org/10.3390/s100606257 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Himmelhaus, Michael
Krishnamoorthy, Sivashankar
Francois, Alexandre
Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
title Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
title_full Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
title_fullStr Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
title_full_unstemmed Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
title_short Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
title_sort optical sensors based on whispering gallery modes in fluorescent microbeads: response to specific interactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247756/
https://www.ncbi.nlm.nih.gov/pubmed/22219711
http://dx.doi.org/10.3390/s100606257
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AT krishnamoorthysivashankar opticalsensorsbasedonwhisperinggallerymodesinfluorescentmicrobeadsresponsetospecificinteractions
AT francoisalexandre opticalsensorsbasedonwhisperinggallerymodesinfluorescentmicrobeadsresponsetospecificinteractions

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