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Cellular Toxicity of Surfactants Used as Herbicide Additives
The cellular toxicities of surfactants, a solvent, and an antifreeze that are included in herbicide formulations were assessed by measuring their effects on membrane integrity, metabolic activity, mitochondrial activity, and total protein synthesis rate in a cell culture. Polyethylene glycol, propyl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247771/ https://www.ncbi.nlm.nih.gov/pubmed/22219606 http://dx.doi.org/10.3346/jkms.2012.27.1.3 |
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author | Song, Ho-Yeon Kim, Young-Hee Seok, Su-Jin Gil, Hyo-Wook Yang, Jong-Oh Lee, Eun-Young Hong, Sae-Yong |
author_facet | Song, Ho-Yeon Kim, Young-Hee Seok, Su-Jin Gil, Hyo-Wook Yang, Jong-Oh Lee, Eun-Young Hong, Sae-Yong |
author_sort | Song, Ho-Yeon |
collection | PubMed |
description | The cellular toxicities of surfactants, a solvent, and an antifreeze that are included in herbicide formulations were assessed by measuring their effects on membrane integrity, metabolic activity, mitochondrial activity, and total protein synthesis rate in a cell culture. Polyethylene glycol, propylene glycol, and monoethylene glycol exhibited no cellular toxicity even at a high concentration of 100 mM. Sodium lauryl ether sulfate and polyoxyethylene lauryl ether significantly damaged the membrane, disturbed cellular metabolic activity, and decreased mitochondrial activity and the protein synthesis rate; however, their toxicity was far below those of the severely toxic chemicals at comparable concentrations. The severely toxic category included polyoxypropylene glycol block copolymer, polyoxyethylene tallow amine, and polyoxyethylene lauryl amine ether. These surfactants were cytotoxic between 3.125 µM and 100 µM in a dose-dependent manner. However, the toxicity graph of concentration vs toxicity had a point of inflection at 25 µM. The slope of the toxicity graph was gentle when the concentration was below 25 µM and steep when the concentration was greater than 25 µM. In conclusion, our results suggest that the toxicity of surfactants be taken care of pertinent treatment of acute herbicide intoxication. |
format | Online Article Text |
id | pubmed-3247771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-32477712012-01-05 Cellular Toxicity of Surfactants Used as Herbicide Additives Song, Ho-Yeon Kim, Young-Hee Seok, Su-Jin Gil, Hyo-Wook Yang, Jong-Oh Lee, Eun-Young Hong, Sae-Yong J Korean Med Sci Original Article The cellular toxicities of surfactants, a solvent, and an antifreeze that are included in herbicide formulations were assessed by measuring their effects on membrane integrity, metabolic activity, mitochondrial activity, and total protein synthesis rate in a cell culture. Polyethylene glycol, propylene glycol, and monoethylene glycol exhibited no cellular toxicity even at a high concentration of 100 mM. Sodium lauryl ether sulfate and polyoxyethylene lauryl ether significantly damaged the membrane, disturbed cellular metabolic activity, and decreased mitochondrial activity and the protein synthesis rate; however, their toxicity was far below those of the severely toxic chemicals at comparable concentrations. The severely toxic category included polyoxypropylene glycol block copolymer, polyoxyethylene tallow amine, and polyoxyethylene lauryl amine ether. These surfactants were cytotoxic between 3.125 µM and 100 µM in a dose-dependent manner. However, the toxicity graph of concentration vs toxicity had a point of inflection at 25 µM. The slope of the toxicity graph was gentle when the concentration was below 25 µM and steep when the concentration was greater than 25 µM. In conclusion, our results suggest that the toxicity of surfactants be taken care of pertinent treatment of acute herbicide intoxication. The Korean Academy of Medical Sciences 2012-01 2011-12-19 /pmc/articles/PMC3247771/ /pubmed/22219606 http://dx.doi.org/10.3346/jkms.2012.27.1.3 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Ho-Yeon Kim, Young-Hee Seok, Su-Jin Gil, Hyo-Wook Yang, Jong-Oh Lee, Eun-Young Hong, Sae-Yong Cellular Toxicity of Surfactants Used as Herbicide Additives |
title | Cellular Toxicity of Surfactants Used as Herbicide Additives |
title_full | Cellular Toxicity of Surfactants Used as Herbicide Additives |
title_fullStr | Cellular Toxicity of Surfactants Used as Herbicide Additives |
title_full_unstemmed | Cellular Toxicity of Surfactants Used as Herbicide Additives |
title_short | Cellular Toxicity of Surfactants Used as Herbicide Additives |
title_sort | cellular toxicity of surfactants used as herbicide additives |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247771/ https://www.ncbi.nlm.nih.gov/pubmed/22219606 http://dx.doi.org/10.3346/jkms.2012.27.1.3 |
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