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Heritability of physical activity traits in Brazilian families: the Baependi Heart Study
BACKGROUND: It is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized. This study aimed to (1) estimate the heritability of physical activity traits in Brazilian families; and (2) investigate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247825/ https://www.ncbi.nlm.nih.gov/pubmed/22126647 http://dx.doi.org/10.1186/1471-2350-12-155 |
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author | Horimoto, Andréa RVR Giolo, Suely R Oliveira, Camila M Alvim, Rafael O Soler, Júlia P de Andrade, Mariza Krieger, José E Pereira, Alexandre C |
author_facet | Horimoto, Andréa RVR Giolo, Suely R Oliveira, Camila M Alvim, Rafael O Soler, Júlia P de Andrade, Mariza Krieger, José E Pereira, Alexandre C |
author_sort | Horimoto, Andréa RVR |
collection | PubMed |
description | BACKGROUND: It is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized. This study aimed to (1) estimate the heritability of physical activity traits in Brazilian families; and (2) investigate whether genetic and environmental variance components contribute differently to the expression of these phenotypes in males and females. METHODS: The sample that constitutes the Baependi Heart Study is comprised of 1,693 individuals in 95 Brazilian families. The phenotypes were self-reported in a questionnaire based on the WHO-MONICA instrument. Variance component approaches, implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package, were applied to estimate the heritability and to evaluate the heterogeneity of variance components by gender on the studied phenotypes. RESULTS: The heritability estimates were intermediate (35%) for weekly physical activity among non-sedentary subjects (weekly PA_NS), and low (9-14%) for sedentarism, weekly physical activity (weekly PA), and level of daily physical activity (daily PA). Significant evidence for heterogeneity in variance components by gender was observed for the sedentarism and weekly PA phenotypes. No significant gender differences in genetic or environmental variance components were observed for the weekly PA_NS trait. The daily PA phenotype was predominantly influenced by environmental factors, with larger effects in males than in females. CONCLUSIONS: Heritability estimates for physical activity phenotypes in this sample of the Brazilian population were significant in both males and females, and varied from low to intermediate magnitude. Significant evidence for heterogeneity in variance components by gender was observed. These data add to the knowledge of the physical activity traits in the Brazilian study population, and are concordant with the notion of significant biological determination in active behavior. |
format | Online Article Text |
id | pubmed-3247825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32478252011-12-30 Heritability of physical activity traits in Brazilian families: the Baependi Heart Study Horimoto, Andréa RVR Giolo, Suely R Oliveira, Camila M Alvim, Rafael O Soler, Júlia P de Andrade, Mariza Krieger, José E Pereira, Alexandre C BMC Med Genet Research Article BACKGROUND: It is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized. This study aimed to (1) estimate the heritability of physical activity traits in Brazilian families; and (2) investigate whether genetic and environmental variance components contribute differently to the expression of these phenotypes in males and females. METHODS: The sample that constitutes the Baependi Heart Study is comprised of 1,693 individuals in 95 Brazilian families. The phenotypes were self-reported in a questionnaire based on the WHO-MONICA instrument. Variance component approaches, implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package, were applied to estimate the heritability and to evaluate the heterogeneity of variance components by gender on the studied phenotypes. RESULTS: The heritability estimates were intermediate (35%) for weekly physical activity among non-sedentary subjects (weekly PA_NS), and low (9-14%) for sedentarism, weekly physical activity (weekly PA), and level of daily physical activity (daily PA). Significant evidence for heterogeneity in variance components by gender was observed for the sedentarism and weekly PA phenotypes. No significant gender differences in genetic or environmental variance components were observed for the weekly PA_NS trait. The daily PA phenotype was predominantly influenced by environmental factors, with larger effects in males than in females. CONCLUSIONS: Heritability estimates for physical activity phenotypes in this sample of the Brazilian population were significant in both males and females, and varied from low to intermediate magnitude. Significant evidence for heterogeneity in variance components by gender was observed. These data add to the knowledge of the physical activity traits in the Brazilian study population, and are concordant with the notion of significant biological determination in active behavior. BioMed Central 2011-11-29 /pmc/articles/PMC3247825/ /pubmed/22126647 http://dx.doi.org/10.1186/1471-2350-12-155 Text en Copyright ©2011 Horimoto et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Horimoto, Andréa RVR Giolo, Suely R Oliveira, Camila M Alvim, Rafael O Soler, Júlia P de Andrade, Mariza Krieger, José E Pereira, Alexandre C Heritability of physical activity traits in Brazilian families: the Baependi Heart Study |
title | Heritability of physical activity traits in Brazilian families: the Baependi Heart Study |
title_full | Heritability of physical activity traits in Brazilian families: the Baependi Heart Study |
title_fullStr | Heritability of physical activity traits in Brazilian families: the Baependi Heart Study |
title_full_unstemmed | Heritability of physical activity traits in Brazilian families: the Baependi Heart Study |
title_short | Heritability of physical activity traits in Brazilian families: the Baependi Heart Study |
title_sort | heritability of physical activity traits in brazilian families: the baependi heart study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247825/ https://www.ncbi.nlm.nih.gov/pubmed/22126647 http://dx.doi.org/10.1186/1471-2350-12-155 |
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