Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia

Tumorigenesis occurs due to synergistic interactions from a complex of signal transduction processes, including multiple onco-proteins and tumor suppressors such as Ras, Myc, PI3K/Akt/mTOR, Her-2/Neu, p53 and PTEN. Specifically, the PI3K/Akt and mTOR pathways have been shown to play a pivotal role o...

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Detalles Bibliográficos
Autores principales: Sacco, Antonio, Roccaro, Aldo, Ghobrial, Irene M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248138/
https://www.ncbi.nlm.nih.gov/pubmed/21317453

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