Targeting Translation Dependence in Cancer

A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. He...

Descripción completa

Detalles Bibliográficos
Autores principales: Malina, Abba, Cencic, Regina, Pelletier, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248143/
https://www.ncbi.nlm.nih.gov/pubmed/21378410
_version_ 1782220201850306560
author Malina, Abba
Cencic, Regina
Pelletier, Jerry
author_facet Malina, Abba
Cencic, Regina
Pelletier, Jerry
author_sort Malina, Abba
collection PubMed
description A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a heterotrimeric complex that integrates multiple signaling inputs to the translation apparatus.
format Online
Article
Text
id pubmed-3248143
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-32481432012-01-18 Targeting Translation Dependence in Cancer Malina, Abba Cencic, Regina Pelletier, Jerry Oncotarget Research Perspectives A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a heterotrimeric complex that integrates multiple signaling inputs to the translation apparatus. Impact Journals LLC 2011-02-15 /pmc/articles/PMC3248143/ /pubmed/21378410 Text en Copyright: © 2011 Malina et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Malina, Abba
Cencic, Regina
Pelletier, Jerry
Targeting Translation Dependence in Cancer
title Targeting Translation Dependence in Cancer
title_full Targeting Translation Dependence in Cancer
title_fullStr Targeting Translation Dependence in Cancer
title_full_unstemmed Targeting Translation Dependence in Cancer
title_short Targeting Translation Dependence in Cancer
title_sort targeting translation dependence in cancer
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248143/
https://www.ncbi.nlm.nih.gov/pubmed/21378410
work_keys_str_mv AT malinaabba targetingtranslationdependenceincancer
AT cencicregina targetingtranslationdependenceincancer
AT pelletierjerry targetingtranslationdependenceincancer

Ejemplares similares