Eradicating cancer cells: struggle with a chameleon

Eradication of cancer stem cells to abrogate tumor growth is a new treatment modality. However, like normal cells cancer cells show plasticity. Differentiated tumor stem cells can acquire stem cell properties when they gain access to the stem cell niche. This indicates that eradicating of stem cells...

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Detalles Bibliográficos
Autores principales: Di, Jiabo, Boer, Tjitske Duiveman-de, Figdor, Carl G., Torensma, Ruurd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248144/
https://www.ncbi.nlm.nih.gov/pubmed/21378413
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author Di, Jiabo
Boer, Tjitske Duiveman-de
Figdor, Carl G.
Torensma, Ruurd
author_facet Di, Jiabo
Boer, Tjitske Duiveman-de
Figdor, Carl G.
Torensma, Ruurd
author_sort Di, Jiabo
collection PubMed
description Eradication of cancer stem cells to abrogate tumor growth is a new treatment modality. However, like normal cells cancer cells show plasticity. Differentiated tumor stem cells can acquire stem cell properties when they gain access to the stem cell niche. This indicates that eradicating of stem cells (emptying of the niche) alone will not lead to eradication of the tumor. Treatment should be directed to cancer stem cells ànd more mature cancer cells.
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spelling pubmed-32481442012-01-18 Eradicating cancer cells: struggle with a chameleon Di, Jiabo Boer, Tjitske Duiveman-de Figdor, Carl G. Torensma, Ruurd Oncotarget Research Perspectives Eradication of cancer stem cells to abrogate tumor growth is a new treatment modality. However, like normal cells cancer cells show plasticity. Differentiated tumor stem cells can acquire stem cell properties when they gain access to the stem cell niche. This indicates that eradicating of stem cells (emptying of the niche) alone will not lead to eradication of the tumor. Treatment should be directed to cancer stem cells ànd more mature cancer cells. Impact Journals LLC 2011-02-28 /pmc/articles/PMC3248144/ /pubmed/21378413 Text en Copyright: © 2011 Di et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Di, Jiabo
Boer, Tjitske Duiveman-de
Figdor, Carl G.
Torensma, Ruurd
Eradicating cancer cells: struggle with a chameleon
title Eradicating cancer cells: struggle with a chameleon
title_full Eradicating cancer cells: struggle with a chameleon
title_fullStr Eradicating cancer cells: struggle with a chameleon
title_full_unstemmed Eradicating cancer cells: struggle with a chameleon
title_short Eradicating cancer cells: struggle with a chameleon
title_sort eradicating cancer cells: struggle with a chameleon
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248144/
https://www.ncbi.nlm.nih.gov/pubmed/21378413
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