The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth

The recent observation that targeted elimination of a minor subpopulation of melanoma cells can lastingly eradicate the tumor lesion provides strong evidence that an established melanoma lesion is hierarchically organized and maintained by definite subset of cells but not by every random cancer cell...

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Detalles Bibliográficos
Autores principales: Schmidt, Patrick, Abken, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248160/
https://www.ncbi.nlm.nih.gov/pubmed/21487158
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author Schmidt, Patrick
Abken, Hinrich
author_facet Schmidt, Patrick
Abken, Hinrich
author_sort Schmidt, Patrick
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description The recent observation that targeted elimination of a minor subpopulation of melanoma cells can lastingly eradicate the tumor lesion provides strong evidence that an established melanoma lesion is hierarchically organized and maintained by definite subset of cells but not by every random cancer cell. This review discusses the concepts of discrete cancer stem cells and of a cellular hierarchy in melanomas, the rationale for shifting therapies from broad tumor cell cytotoxicity into selective cancer cell elimination strategies and the challenges for future therapeutic concepts.
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spelling pubmed-32481602012-01-18 The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth Schmidt, Patrick Abken, Hinrich Oncotarget Research Perspectives The recent observation that targeted elimination of a minor subpopulation of melanoma cells can lastingly eradicate the tumor lesion provides strong evidence that an established melanoma lesion is hierarchically organized and maintained by definite subset of cells but not by every random cancer cell. This review discusses the concepts of discrete cancer stem cells and of a cellular hierarchy in melanomas, the rationale for shifting therapies from broad tumor cell cytotoxicity into selective cancer cell elimination strategies and the challenges for future therapeutic concepts. Impact Journals LLC 2011-04-10 /pmc/articles/PMC3248160/ /pubmed/21487158 Text en Copyright: © 2011 Schmidt and Abken http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Schmidt, Patrick
Abken, Hinrich
The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
title The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
title_full The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
title_fullStr The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
title_full_unstemmed The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
title_short The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
title_sort beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248160/
https://www.ncbi.nlm.nih.gov/pubmed/21487158
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