Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link

The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing over the last years. A recent study identifie...

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Detalles Bibliográficos
Autor principal: Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248183/
https://www.ncbi.nlm.nih.gov/pubmed/21789791
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author Fulda, Simone
author_facet Fulda, Simone
author_sort Fulda, Simone
collection PubMed
description The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing over the last years. A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib.
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spelling pubmed-32481832012-01-18 Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link Fulda, Simone Oncotarget Research Perspectives The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing over the last years. A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib. Impact Journals LLC 2011-05-16 /pmc/articles/PMC3248183/ /pubmed/21789791 Text en Copyright: © 2011 Fulda http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Fulda, Simone
Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
title Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
title_full Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
title_fullStr Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
title_full_unstemmed Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
title_short Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
title_sort novel insights into the synergistic interaction of bortezomib and trail: tbid provides the link
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248183/
https://www.ncbi.nlm.nih.gov/pubmed/21789791
work_keys_str_mv AT fuldasimone novelinsightsintothesynergisticinteractionofbortezomibandtrailtbidprovidesthelink

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