Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

The molecular chaperone Heat Shock Protein 90 (Hsp90) is essential for the function of various oncoproteins that are vital components of multiple signaling networks regulating cancer cell proliferation, survival, and metastasis. Hsp90 chaperone function is coupled to its ATPase activity, which can b...

Descripción completa

Detalles Bibliográficos
Autores principales: Mollapour, Mehdi, Tsutsumi, Shinji, Kim, Yeong Sang, Trepel, Jane, Neckers, Len
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248188/
https://www.ncbi.nlm.nih.gov/pubmed/21576760

Ejemplares similares

Ejemplares similares