DNaseI Hypersensitivity and Ultraconservation Reveal Novel, Interdependent Long-Range Enhancers at the Complex Pax6 Cis-Regulatory Region

The PAX6 gene plays a crucial role in development of the eye, brain, olfactory system and endocrine pancreas. Consistent with its pleiotropic role the gene exhibits a complex developmental expression pattern which is subject to strict spatial, temporal and quantitative regulation. Control of express...

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Detalles Bibliográficos
Autores principales: McBride, David J., Buckle, Adam, van Heyningen, Veronica, Kleinjan, Dirk A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248410/
https://www.ncbi.nlm.nih.gov/pubmed/22220192
http://dx.doi.org/10.1371/journal.pone.0028616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248410/
https://www.ncbi.nlm.nih.gov/pubmed/22220192
http://dx.doi.org/10.1371/journal.pone.0028616

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