The Shc Family Protein Adaptor, Rai, Negatively Regulates T Cell Antigen Receptor Signaling by Inhibiting ZAP-70 Recruitment and Activation

Rai/ShcC is a member of the Shc family of protein adaptors expressed with the highest abundance in the central nervous system, where it exerts a protective function by coupling neurotrophic receptors to the PI3K/Akt survival pathway. Rai is also expressed, albeit at lower levels, in other cell types...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferro, Micol, Savino, Maria Teresa, Ortensi, Barbara, Finetti, Francesca, Genovese, Luca, Masi, Giulia, Ulivieri, Cristina, Benati, Daniela, Pelicci, Giuliana, Baldari, Cosima T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248456/
https://www.ncbi.nlm.nih.gov/pubmed/22242145
http://dx.doi.org/10.1371/journal.pone.0029899

Ejemplares similares

Ejemplares similares