Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits such as height is uncertain...

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Detalles Bibliográficos
Autores principales: Chan, Yingleong, Holmen, Oddgeir L., Dauber, Andrew, Vatten, Lars, Havulinna, Aki S., Skorpen, Frank, Kvaløy, Kirsti, Silander, Kaisa, Nguyen, Thutrang T., Willer, Cristen, Boehnke, Michael, Perola, Markus, Palotie, Aarno, Salomaa, Veikko, Hveem, Kristian, Frayling, Timothy M., Hirschhorn, Joel N., Weedon, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248463/
https://www.ncbi.nlm.nih.gov/pubmed/22242009
http://dx.doi.org/10.1371/journal.pgen.1002439

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