Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

Burkholderia pseudomallei is a Gram-negative bacterium that infects macrophages and other cell types and causes melioidosis. The interaction of B. pseudomallei with the inflammasome and the role of pyroptosis, IL-1β, and IL-18 during melioidosis have not been investigated in detail. Here we show tha...

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Detalles Bibliográficos
Autores principales: Ceballos-Olvera, Ivonne, Sahoo, Manoranjan, Miller, Mark A., del Barrio, Laura, Re, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248555/
https://www.ncbi.nlm.nih.gov/pubmed/22241982
http://dx.doi.org/10.1371/journal.ppat.1002452

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