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Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes

OBJECTIVE: Hypoxia-inducible factor 1 alpha regulates genes related to cellular survival under hypoxia. This factor is present in osteroarthritic chondrocytes, and cytokines, such as interleukin-1 beta, participate in the pathogenesis of osteoarthritis, thereby increasing the activities of proteolyt...

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Detalles Bibliográficos
Autores principales:	Sartori-Cintra, Angélica Rossi, de Mara, Cristiane Sampaio, Argolo, Danielle L., Coimbra, Ibsen Bellini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Materias:	Clinical Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248599/ https://www.ncbi.nlm.nih.gov/pubmed/22249478 http://dx.doi.org/10.6061/clinics/2012(01)06

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