Identification of Ghrelin Receptor Blocker, D-[Lys3] GHRP-6 as a CXCR4 Receptor Antagonist

[D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. Unexpectedly, we identified that DLS also has the ability to block CXCL12 binding and activity through CXCR4 on T cells and peripheral blood mononuclear cells...

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Detalles Bibliográficos
Autores principales: Patel, Kalpesh, Dixit, Vishwa Deep, Lee, Jun Ho, Kim, Jie Wan, Schaffer, Eric M., Nguyen, Dzung, Taub, Dennis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248652/
https://www.ncbi.nlm.nih.gov/pubmed/22211109

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