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Papillomavirus E5: the smallest oncoprotein with many functions
Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the etiopathogenesis of other cancer types. The early oncopro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248866/ https://www.ncbi.nlm.nih.gov/pubmed/22078316 http://dx.doi.org/10.1186/1476-4598-10-140 |
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author | Venuti, Aldo Paolini, Francesca Nasir, Lubna Corteggio, Annunziata Roperto, Sante Campo, Maria S Borzacchiello, Giuseppe |
author_facet | Venuti, Aldo Paolini, Francesca Nasir, Lubna Corteggio, Annunziata Roperto, Sante Campo, Maria S Borzacchiello, Giuseppe |
author_sort | Venuti, Aldo |
collection | PubMed |
description | Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the etiopathogenesis of other cancer types. The early oncoproteins of PVs: E5, E6 and E7 are known to contribute to tumour progression. While the oncogenic activities of E6 and E7 are well characterised, the role of E5 is still rather nebulous. The widespread causal association of PVs with cancer makes their study worthwhile not only in humans but also in animal model systems. The Bovine PV (BPV) system has been the most useful animal model in understanding the oncogenic potential of PVs due to the pivotal role of its E5 oncoprotein in cell transformation. This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent. |
format | Online Article Text |
id | pubmed-3248866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32488662011-12-31 Papillomavirus E5: the smallest oncoprotein with many functions Venuti, Aldo Paolini, Francesca Nasir, Lubna Corteggio, Annunziata Roperto, Sante Campo, Maria S Borzacchiello, Giuseppe Mol Cancer Review Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the etiopathogenesis of other cancer types. The early oncoproteins of PVs: E5, E6 and E7 are known to contribute to tumour progression. While the oncogenic activities of E6 and E7 are well characterised, the role of E5 is still rather nebulous. The widespread causal association of PVs with cancer makes their study worthwhile not only in humans but also in animal model systems. The Bovine PV (BPV) system has been the most useful animal model in understanding the oncogenic potential of PVs due to the pivotal role of its E5 oncoprotein in cell transformation. This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent. BioMed Central 2011-11-11 /pmc/articles/PMC3248866/ /pubmed/22078316 http://dx.doi.org/10.1186/1476-4598-10-140 Text en Copyright ©2011 Venuti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Venuti, Aldo Paolini, Francesca Nasir, Lubna Corteggio, Annunziata Roperto, Sante Campo, Maria S Borzacchiello, Giuseppe Papillomavirus E5: the smallest oncoprotein with many functions |
title | Papillomavirus E5: the smallest oncoprotein with many functions |
title_full | Papillomavirus E5: the smallest oncoprotein with many functions |
title_fullStr | Papillomavirus E5: the smallest oncoprotein with many functions |
title_full_unstemmed | Papillomavirus E5: the smallest oncoprotein with many functions |
title_short | Papillomavirus E5: the smallest oncoprotein with many functions |
title_sort | papillomavirus e5: the smallest oncoprotein with many functions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248866/ https://www.ncbi.nlm.nih.gov/pubmed/22078316 http://dx.doi.org/10.1186/1476-4598-10-140 |
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