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Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data
BACKGROUND: Psychotic conditions and especially schizophrenia, have been associated with increased morbidity and mortality. Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248871/ https://www.ncbi.nlm.nih.gov/pubmed/22126584 http://dx.doi.org/10.1186/1471-2296-12-132 |
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author | Truyers, Carla Buntinx, Frank De Lepeleire, Jan De Hert, Marc Van Winkel, Ruud Aertgeerts, Bert Bartholomeeusen, Stefaan Lesaffre, Emmanuel |
author_facet | Truyers, Carla Buntinx, Frank De Lepeleire, Jan De Hert, Marc Van Winkel, Ruud Aertgeerts, Bert Bartholomeeusen, Stefaan Lesaffre, Emmanuel |
author_sort | Truyers, Carla |
collection | PubMed |
description | BACKGROUND: Psychotic conditions and especially schizophrenia, have been associated with increased morbidity and mortality. Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network. METHODS: Hazard ratios are presented resulting from frailty models to assess the risk of subsequent somatic disease after a diagnosis of psychosis compared to people without psychosis matched on practice, age and gender. Diseases studied are cancer, physical trauma, diabetes mellitus, gastrointestinal disorders, joint disorders, irritable bowel syndrome, general infections, metabolic disorders other than diabetes, hearing and vision problems, anemia, cardiovascular disease, alcohol abuse, lung disorders, mouth and teeth problems, sexually transmitted diseases. RESULTS: Significant higher risks after a diagnosis of psychosis were found for the emergence of diabetes, physical trauma, gastrointestinal disorders, alcohol abuse, chronic lung disease and teeth and mouth problems. With regard to diabetes, by including the type of antipsychotic medication it is clear that the significant overall effect was largely due to the use of atypical antipsychotic medication. No significant higher risk was seen for cancer, joint conditions, irritable bowel syndrome, general infections, other metabolic conditions, hearing/vision problems, anaemia, cardiovascular disease or diabetes, in case no atypical antipsychotic medication was used. CONCLUSION: Significantly higher morbidity rates for some somatic conditions in patients with psychosis are apparent. People with a diagnosis of psychosis benefit from regular assessments for the emergence of somatic disorders and risk factors, including diabetes in case of atypical antipsychotic medication. |
format | Online Article Text |
id | pubmed-3248871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32488712012-01-03 Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data Truyers, Carla Buntinx, Frank De Lepeleire, Jan De Hert, Marc Van Winkel, Ruud Aertgeerts, Bert Bartholomeeusen, Stefaan Lesaffre, Emmanuel BMC Fam Pract Research Article BACKGROUND: Psychotic conditions and especially schizophrenia, have been associated with increased morbidity and mortality. Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network. METHODS: Hazard ratios are presented resulting from frailty models to assess the risk of subsequent somatic disease after a diagnosis of psychosis compared to people without psychosis matched on practice, age and gender. Diseases studied are cancer, physical trauma, diabetes mellitus, gastrointestinal disorders, joint disorders, irritable bowel syndrome, general infections, metabolic disorders other than diabetes, hearing and vision problems, anemia, cardiovascular disease, alcohol abuse, lung disorders, mouth and teeth problems, sexually transmitted diseases. RESULTS: Significant higher risks after a diagnosis of psychosis were found for the emergence of diabetes, physical trauma, gastrointestinal disorders, alcohol abuse, chronic lung disease and teeth and mouth problems. With regard to diabetes, by including the type of antipsychotic medication it is clear that the significant overall effect was largely due to the use of atypical antipsychotic medication. No significant higher risk was seen for cancer, joint conditions, irritable bowel syndrome, general infections, other metabolic conditions, hearing/vision problems, anaemia, cardiovascular disease or diabetes, in case no atypical antipsychotic medication was used. CONCLUSION: Significantly higher morbidity rates for some somatic conditions in patients with psychosis are apparent. People with a diagnosis of psychosis benefit from regular assessments for the emergence of somatic disorders and risk factors, including diabetes in case of atypical antipsychotic medication. BioMed Central 2011-11-29 /pmc/articles/PMC3248871/ /pubmed/22126584 http://dx.doi.org/10.1186/1471-2296-12-132 Text en Copyright ©2011 Truyers et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Truyers, Carla Buntinx, Frank De Lepeleire, Jan De Hert, Marc Van Winkel, Ruud Aertgeerts, Bert Bartholomeeusen, Stefaan Lesaffre, Emmanuel Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data |
title | Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data |
title_full | Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data |
title_fullStr | Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data |
title_full_unstemmed | Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data |
title_short | Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data |
title_sort | incident somatic comorbidity after psychosis: results from a retrospective cohort study based on flemish general practice data |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248871/ https://www.ncbi.nlm.nih.gov/pubmed/22126584 http://dx.doi.org/10.1186/1471-2296-12-132 |
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