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MicroRNA networks direct neuronal development and plasticity
MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal develo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SP Birkhäuser Verlag Basel
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249201/ https://www.ncbi.nlm.nih.gov/pubmed/21833581 http://dx.doi.org/10.1007/s00018-011-0788-1 |
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author | Olde Loohuis, N. F. M. Kos, A. Martens, G. J. M. Van Bokhoven, H. Nadif Kasri, N. Aschrafi, A. |
author_facet | Olde Loohuis, N. F. M. Kos, A. Martens, G. J. M. Van Bokhoven, H. Nadif Kasri, N. Aschrafi, A. |
author_sort | Olde Loohuis, N. F. M. |
collection | PubMed |
description | MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal development and maturation, including neurite outgrowth, dendritogenesis, and spine formation. Notably, miRNAs regulate mRNA translation locally in the axosomal and synaptodendritic compartments, and thereby contribute to the dynamic spatial organization of axonal and dendritic structures and their function. Given the critical role for miRNAs in regulating early brain development and in mediating synaptic plasticity later in life, it is tempting to speculate that the pathology of neurological disorders is affected by altered expression or functioning of miRNAs. Here we provide an overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation. |
format | Online Article Text |
id | pubmed-3249201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SP Birkhäuser Verlag Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-32492012012-01-11 MicroRNA networks direct neuronal development and plasticity Olde Loohuis, N. F. M. Kos, A. Martens, G. J. M. Van Bokhoven, H. Nadif Kasri, N. Aschrafi, A. Cell Mol Life Sci Review MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal development and maturation, including neurite outgrowth, dendritogenesis, and spine formation. Notably, miRNAs regulate mRNA translation locally in the axosomal and synaptodendritic compartments, and thereby contribute to the dynamic spatial organization of axonal and dendritic structures and their function. Given the critical role for miRNAs in regulating early brain development and in mediating synaptic plasticity later in life, it is tempting to speculate that the pathology of neurological disorders is affected by altered expression or functioning of miRNAs. Here we provide an overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation. SP Birkhäuser Verlag Basel 2011-08-11 2012 /pmc/articles/PMC3249201/ /pubmed/21833581 http://dx.doi.org/10.1007/s00018-011-0788-1 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Olde Loohuis, N. F. M. Kos, A. Martens, G. J. M. Van Bokhoven, H. Nadif Kasri, N. Aschrafi, A. MicroRNA networks direct neuronal development and plasticity |
title | MicroRNA networks direct neuronal development and plasticity |
title_full | MicroRNA networks direct neuronal development and plasticity |
title_fullStr | MicroRNA networks direct neuronal development and plasticity |
title_full_unstemmed | MicroRNA networks direct neuronal development and plasticity |
title_short | MicroRNA networks direct neuronal development and plasticity |
title_sort | microrna networks direct neuronal development and plasticity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249201/ https://www.ncbi.nlm.nih.gov/pubmed/21833581 http://dx.doi.org/10.1007/s00018-011-0788-1 |
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