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Outcome of Limited Resection for Lung Cancer

BACKGROUND: Up to now, lobectomy, bilobectomy and pneumonectomy combined with extensive lymph node dissection have been regarded as the standard procedures for non-small cell lung cancer (NSCLC). In high-risk patients, however, limited resection (LR) has been attempted as a salvage procedure, and, r...

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Autores principales: Cho, Jeong Su, Jheon, Sanghoon, Park, Sung Joon, Sung, Sook-Whan, Lee, Choon Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Thoracic and Cardiovascular Surgery 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249273/
https://www.ncbi.nlm.nih.gov/pubmed/22263124
http://dx.doi.org/10.5090/kjtcs.2011.44.1.51
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author Cho, Jeong Su
Jheon, Sanghoon
Park, Sung Joon
Sung, Sook-Whan
Lee, Choon Taek
author_facet Cho, Jeong Su
Jheon, Sanghoon
Park, Sung Joon
Sung, Sook-Whan
Lee, Choon Taek
author_sort Cho, Jeong Su
collection PubMed
description BACKGROUND: Up to now, lobectomy, bilobectomy and pneumonectomy combined with extensive lymph node dissection have been regarded as the standard procedures for non-small cell lung cancer (NSCLC). In high-risk patients, however, limited resection (LR) has been attempted as a salvage procedure, and, recently, indication for LR has been extended to selected cases with early-stage NSCLC. MATERIAL AND METHODS: Among the 773 patients who underwent surgical procedures for NSCLC in Seoul National University Bundang Hospital from May 2003 to December 2008, 43 patients received LR. Medical records of these patients were retrospectively reviewed. RESULTS: Mean age at operation was 66.0±12.4 years, and there were 30 males. Twenty-five patients underwent conservative limited resection (CLR) and 18 underwent intentional limited resection (ILR). Indications for CLR were multiple primary lung cancer in 9 (9/25, 36%) and severe concomitant diseases in 5 (5/25, 20%). Of these, 6 patients underwent segmentectomy and 19 received wedge resection. During the follow-up period of 28.0±17.8 months, 15 patient developed recurrent lung cancer. ILR was selectively performed in lesions almost purely composed of ground glass opacity (≥95%), or in small solid lesions (≤2 cm). Of these, 11 patients underwent segmentectomy and 7 underwent wedge resection. During the follow-up period of 31.7±11.6 months, no patient developed recurrence. CONCLUSION: Intermediate-term outcome of LR for early-stage lung cancer is comparable to that of standard operation. For the delineation of the indications and appropriate surgical techniques for LR, prospective randomized multi-institutional study may be expedient.
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spelling pubmed-32492732012-01-19 Outcome of Limited Resection for Lung Cancer Cho, Jeong Su Jheon, Sanghoon Park, Sung Joon Sung, Sook-Whan Lee, Choon Taek Korean J Thorac Cardiovasc Surg Clinical Research BACKGROUND: Up to now, lobectomy, bilobectomy and pneumonectomy combined with extensive lymph node dissection have been regarded as the standard procedures for non-small cell lung cancer (NSCLC). In high-risk patients, however, limited resection (LR) has been attempted as a salvage procedure, and, recently, indication for LR has been extended to selected cases with early-stage NSCLC. MATERIAL AND METHODS: Among the 773 patients who underwent surgical procedures for NSCLC in Seoul National University Bundang Hospital from May 2003 to December 2008, 43 patients received LR. Medical records of these patients were retrospectively reviewed. RESULTS: Mean age at operation was 66.0±12.4 years, and there were 30 males. Twenty-five patients underwent conservative limited resection (CLR) and 18 underwent intentional limited resection (ILR). Indications for CLR were multiple primary lung cancer in 9 (9/25, 36%) and severe concomitant diseases in 5 (5/25, 20%). Of these, 6 patients underwent segmentectomy and 19 received wedge resection. During the follow-up period of 28.0±17.8 months, 15 patient developed recurrent lung cancer. ILR was selectively performed in lesions almost purely composed of ground glass opacity (≥95%), or in small solid lesions (≤2 cm). Of these, 11 patients underwent segmentectomy and 7 underwent wedge resection. During the follow-up period of 31.7±11.6 months, no patient developed recurrence. CONCLUSION: Intermediate-term outcome of LR for early-stage lung cancer is comparable to that of standard operation. For the delineation of the indications and appropriate surgical techniques for LR, prospective randomized multi-institutional study may be expedient. Korean Society for Thoracic and Cardiovascular Surgery 2011-02 2011-02-12 /pmc/articles/PMC3249273/ /pubmed/22263124 http://dx.doi.org/10.5090/kjtcs.2011.44.1.51 Text en © The Korean Society for Thoracic and Cardiovascular Surgery. 2011. All right reserved. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Cho, Jeong Su
Jheon, Sanghoon
Park, Sung Joon
Sung, Sook-Whan
Lee, Choon Taek
Outcome of Limited Resection for Lung Cancer
title Outcome of Limited Resection for Lung Cancer
title_full Outcome of Limited Resection for Lung Cancer
title_fullStr Outcome of Limited Resection for Lung Cancer
title_full_unstemmed Outcome of Limited Resection for Lung Cancer
title_short Outcome of Limited Resection for Lung Cancer
title_sort outcome of limited resection for lung cancer
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249273/
https://www.ncbi.nlm.nih.gov/pubmed/22263124
http://dx.doi.org/10.5090/kjtcs.2011.44.1.51
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