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Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys

Although the arrangement of the corticospinal projection in primates is consistent with a more prominent role of the ipsilateral motor cortex on proximal muscles, rather than on distal muscles involved in manual dexterity, the role played by the primary motor cortex on the control of manual dexterit...

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Autores principales: Bashir, Shahid, Kaeser, Mélanie, Wyss, Alexander, Hamadjida, Adjia, Liu, Yu, Bloch, Jocelyne, Brunet, Jean-François, Belhaj-Saif, Abderraouf, Rouiller, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249543/
https://www.ncbi.nlm.nih.gov/pubmed/21597965
http://dx.doi.org/10.1007/s00429-011-0327-8
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author Bashir, Shahid
Kaeser, Mélanie
Wyss, Alexander
Hamadjida, Adjia
Liu, Yu
Bloch, Jocelyne
Brunet, Jean-François
Belhaj-Saif, Abderraouf
Rouiller, Eric M.
author_facet Bashir, Shahid
Kaeser, Mélanie
Wyss, Alexander
Hamadjida, Adjia
Liu, Yu
Bloch, Jocelyne
Brunet, Jean-François
Belhaj-Saif, Abderraouf
Rouiller, Eric M.
author_sort Bashir, Shahid
collection PubMed
description Although the arrangement of the corticospinal projection in primates is consistent with a more prominent role of the ipsilateral motor cortex on proximal muscles, rather than on distal muscles involved in manual dexterity, the role played by the primary motor cortex on the control of manual dexterity for the ipsilateral hand remains a matter a debate, either in the normal function or after a lesion. We, therefore, tested the impact of permanent unilateral motor cortex lesion on the manual dexterity of the ipsilateral hand in 11 macaque monkeys, within a time window of 60 days post-lesion. For comparison, unilateral reversible pharmacological inactivation of the motor cortex was produced in an additional monkey. Manual dexterity was assessed quantitatively based on three motor parameters derived from two reach and grasp manual tasks. In contrast to the expected dramatic, complete deficit of manual dexterity of the contralesional hand that persists for several weeks, the impact on the manual dexterity of the ipsilesional hand was generally moderate (but statistically significant) and, when present, lasted less than 20 days. Out of the 11 monkeys, only 3 showed a deficit of the ipsilesional hand for 2 of the 3 motor parameters, and 4 animals had a deficit for only one motor parameter. Four monkeys did not show any deficit. The reversible inactivation experiment yielded results consistent with the permanent lesion data. In conclusion, the primary motor cortex exerts a modest role on ipsilateral manual dexterity, most likely in the form of indirect hand postural control.
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spelling pubmed-32495432012-01-11 Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys Bashir, Shahid Kaeser, Mélanie Wyss, Alexander Hamadjida, Adjia Liu, Yu Bloch, Jocelyne Brunet, Jean-François Belhaj-Saif, Abderraouf Rouiller, Eric M. Brain Struct Funct Original Article Although the arrangement of the corticospinal projection in primates is consistent with a more prominent role of the ipsilateral motor cortex on proximal muscles, rather than on distal muscles involved in manual dexterity, the role played by the primary motor cortex on the control of manual dexterity for the ipsilateral hand remains a matter a debate, either in the normal function or after a lesion. We, therefore, tested the impact of permanent unilateral motor cortex lesion on the manual dexterity of the ipsilateral hand in 11 macaque monkeys, within a time window of 60 days post-lesion. For comparison, unilateral reversible pharmacological inactivation of the motor cortex was produced in an additional monkey. Manual dexterity was assessed quantitatively based on three motor parameters derived from two reach and grasp manual tasks. In contrast to the expected dramatic, complete deficit of manual dexterity of the contralesional hand that persists for several weeks, the impact on the manual dexterity of the ipsilesional hand was generally moderate (but statistically significant) and, when present, lasted less than 20 days. Out of the 11 monkeys, only 3 showed a deficit of the ipsilesional hand for 2 of the 3 motor parameters, and 4 animals had a deficit for only one motor parameter. Four monkeys did not show any deficit. The reversible inactivation experiment yielded results consistent with the permanent lesion data. In conclusion, the primary motor cortex exerts a modest role on ipsilateral manual dexterity, most likely in the form of indirect hand postural control. Springer-Verlag 2011-05-20 2012 /pmc/articles/PMC3249543/ /pubmed/21597965 http://dx.doi.org/10.1007/s00429-011-0327-8 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Bashir, Shahid
Kaeser, Mélanie
Wyss, Alexander
Hamadjida, Adjia
Liu, Yu
Bloch, Jocelyne
Brunet, Jean-François
Belhaj-Saif, Abderraouf
Rouiller, Eric M.
Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys
title Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys
title_full Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys
title_fullStr Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys
title_full_unstemmed Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys
title_short Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys
title_sort short-term effects of unilateral lesion of the primary motor cortex (m1) on ipsilesional hand dexterity in adult macaque monkeys
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249543/
https://www.ncbi.nlm.nih.gov/pubmed/21597965
http://dx.doi.org/10.1007/s00429-011-0327-8
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