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The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study
PURPOSE: To examine the natural course and outcome of major depressive disorder (MDD) in primary care over 39 months. METHODS: Prospective cohort study of 1,338 consecutive attendees with follow-up after 6, 12, and 39 months with DSM-IV MDD using the Composite International Diagnostic Interview (CID...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249585/ https://www.ncbi.nlm.nih.gov/pubmed/21057769 http://dx.doi.org/10.1007/s00127-010-0317-9 |
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author | Stegenga, Bauke T. Kamphuis, Marjolein H. King, Michael Nazareth, Irwin Geerlings, Mirjam I. |
author_facet | Stegenga, Bauke T. Kamphuis, Marjolein H. King, Michael Nazareth, Irwin Geerlings, Mirjam I. |
author_sort | Stegenga, Bauke T. |
collection | PubMed |
description | PURPOSE: To examine the natural course and outcome of major depressive disorder (MDD) in primary care over 39 months. METHODS: Prospective cohort study of 1,338 consecutive attendees with follow-up after 6, 12, and 39 months with DSM-IV MDD using the Composite International Diagnostic Interview (CIDI). We measured severity of depressive symptoms (Patient Health Questionnaire 9), somatic symptoms (Patient Health Questionnaire 15), and mental and physical function (Short Form 12, mental and physical component summary). Analysis of variance and random coefficient models were performed. RESULTS: At baseline, 174 people (13%) had MDD of which 17% had a chronic and 40% had a fluctuating course, while 43% remitted. Patients with chronic courses had more severe depressive symptoms (mean difference 6.54; 95% CI 4.38–8.70), somatic symptoms (mean difference 3.31; 95% CI 1.61–5.02), and greater mental dysfunction (mean difference −10.49; 95% CI −14.42 to −6.57) at baseline than those who remitted from baseline, independent of age, sex, level of education, presence of a chronic disease, and a lifetime history of depression. CONCLUSIONS: Although 43% of patients with MDD attending primary care recover, this leaves a majority of patients (57%) who have a chronic or intermittent course. Chronic courses are associated with higher levels of depressive symptoms and somatic symptoms and greater mental dysfunction at baseline. |
format | Online Article Text |
id | pubmed-3249585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-32495852012-01-11 The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study Stegenga, Bauke T. Kamphuis, Marjolein H. King, Michael Nazareth, Irwin Geerlings, Mirjam I. Soc Psychiatry Psychiatr Epidemiol Original Paper PURPOSE: To examine the natural course and outcome of major depressive disorder (MDD) in primary care over 39 months. METHODS: Prospective cohort study of 1,338 consecutive attendees with follow-up after 6, 12, and 39 months with DSM-IV MDD using the Composite International Diagnostic Interview (CIDI). We measured severity of depressive symptoms (Patient Health Questionnaire 9), somatic symptoms (Patient Health Questionnaire 15), and mental and physical function (Short Form 12, mental and physical component summary). Analysis of variance and random coefficient models were performed. RESULTS: At baseline, 174 people (13%) had MDD of which 17% had a chronic and 40% had a fluctuating course, while 43% remitted. Patients with chronic courses had more severe depressive symptoms (mean difference 6.54; 95% CI 4.38–8.70), somatic symptoms (mean difference 3.31; 95% CI 1.61–5.02), and greater mental dysfunction (mean difference −10.49; 95% CI −14.42 to −6.57) at baseline than those who remitted from baseline, independent of age, sex, level of education, presence of a chronic disease, and a lifetime history of depression. CONCLUSIONS: Although 43% of patients with MDD attending primary care recover, this leaves a majority of patients (57%) who have a chronic or intermittent course. Chronic courses are associated with higher levels of depressive symptoms and somatic symptoms and greater mental dysfunction at baseline. Springer-Verlag 2010-11-06 2012 /pmc/articles/PMC3249585/ /pubmed/21057769 http://dx.doi.org/10.1007/s00127-010-0317-9 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Paper Stegenga, Bauke T. Kamphuis, Marjolein H. King, Michael Nazareth, Irwin Geerlings, Mirjam I. The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study |
title | The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study |
title_full | The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study |
title_fullStr | The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study |
title_full_unstemmed | The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study |
title_short | The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study |
title_sort | natural course and outcome of major depressive disorder in primary care: the predict-nl study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249585/ https://www.ncbi.nlm.nih.gov/pubmed/21057769 http://dx.doi.org/10.1007/s00127-010-0317-9 |
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