Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs

The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2 –yl)methy...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhat, KI, Sufeera, K, Chaitanya, Sunil Kumar P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Pharmaceutical Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249744/
https://www.ncbi.nlm.nih.gov/pubmed/22224038
http://dx.doi.org/10.4103/0975-1483.90243
_version_ 1782220376961449984
author Bhat, KI
Sufeera, K
Chaitanya, Sunil Kumar P
author_facet Bhat, KI
Sufeera, K
Chaitanya, Sunil Kumar P
author_sort Bhat, KI
collection PubMed
description The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2 –yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, (1)HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities.
format Online
Article
Text
id pubmed-3249744
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-32497442012-01-05 Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs Bhat, KI Sufeera, K Chaitanya, Sunil Kumar P J Young Pharm Pharmaceutical Chemistry The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2 –yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, (1)HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3249744/ /pubmed/22224038 http://dx.doi.org/10.4103/0975-1483.90243 Text en Copyright: © Journal of Young Pharmacists http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmaceutical Chemistry
Bhat, KI
Sufeera, K
Chaitanya, Sunil Kumar P
Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
title Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
title_full Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
title_fullStr Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
title_full_unstemmed Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
title_short Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
title_sort synthesis, characterization and biological activity studies of 1,3,4-oxadiazole analogs
topic Pharmaceutical Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249744/
https://www.ncbi.nlm.nih.gov/pubmed/22224038
http://dx.doi.org/10.4103/0975-1483.90243
work_keys_str_mv AT bhatki synthesischaracterizationandbiologicalactivitystudiesof134oxadiazoleanalogs
AT sufeerak synthesischaracterizationandbiologicalactivitystudiesof134oxadiazoleanalogs
AT chaitanyasunilkumarp synthesischaracterizationandbiologicalactivitystudiesof134oxadiazoleanalogs

Ejemplares similares