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Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer
BACKGROUND: Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical eval...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249781/ https://www.ncbi.nlm.nih.gov/pubmed/22224045 http://dx.doi.org/10.4103/0974-8490.89742 |
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author | Prabha, P. Karpagam, Thirunethiran Varalakshmi, B. Packiavathy, A. Sohna Chandra |
author_facet | Prabha, P. Karpagam, Thirunethiran Varalakshmi, B. Packiavathy, A. Sohna Chandra |
author_sort | Prabha, P. |
collection | PubMed |
description | BACKGROUND: Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical evaluation of antiulcer drugs showed tolerance, incidence of relapses and side-effects that make their efficacy arguable. An indigenous drug like Musa sapientum possessing fewer side-effects is the major thrust area of present day research, aiming at a better and safer approach for the management of PUD. MATERIAL AND METHODS: The unripe plantain bananas (Musa sapientum) were shade-dried, powdered and used for phytochemical analysis and as antiulcer drug. In our present study Group I rats served as control and were treated with saline, Group II was indomethacin-induced ulcerated rats, Group III received aqueous extract of Musa sapientum along with indomethacin and Group IV received esomeprazole along with indomethacin for 21 days. The anti-ulcerogenic activity was investigated by performing hematological, mucosal, antioxidant profile in comparison with the standard drug esomeprazole. RESULTS: Our findings from High - Performance Thin Layer Chromatography (HPTLC) analysis showed that Musa sapientum has an active compound a monomeric flavonoid (leucocyanidin) with anti-ulcerogenic activity. Results were expressed as mean ± SD. All our results are in congruous with the results of standard drug esomeprazole. CONCLUSION: It could be clearly concluded that administration of the aqueous extract of Musa sapientum at the dose used in this study tends to ameliorate ulcers. Its use in indigenous medicine should be scientifically scrutinized with further research. |
format | Online Article Text |
id | pubmed-3249781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32497812012-01-05 Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer Prabha, P. Karpagam, Thirunethiran Varalakshmi, B. Packiavathy, A. Sohna Chandra Pharmacognosy Res Original Article BACKGROUND: Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical evaluation of antiulcer drugs showed tolerance, incidence of relapses and side-effects that make their efficacy arguable. An indigenous drug like Musa sapientum possessing fewer side-effects is the major thrust area of present day research, aiming at a better and safer approach for the management of PUD. MATERIAL AND METHODS: The unripe plantain bananas (Musa sapientum) were shade-dried, powdered and used for phytochemical analysis and as antiulcer drug. In our present study Group I rats served as control and were treated with saline, Group II was indomethacin-induced ulcerated rats, Group III received aqueous extract of Musa sapientum along with indomethacin and Group IV received esomeprazole along with indomethacin for 21 days. The anti-ulcerogenic activity was investigated by performing hematological, mucosal, antioxidant profile in comparison with the standard drug esomeprazole. RESULTS: Our findings from High - Performance Thin Layer Chromatography (HPTLC) analysis showed that Musa sapientum has an active compound a monomeric flavonoid (leucocyanidin) with anti-ulcerogenic activity. Results were expressed as mean ± SD. All our results are in congruous with the results of standard drug esomeprazole. CONCLUSION: It could be clearly concluded that administration of the aqueous extract of Musa sapientum at the dose used in this study tends to ameliorate ulcers. Its use in indigenous medicine should be scientifically scrutinized with further research. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3249781/ /pubmed/22224045 http://dx.doi.org/10.4103/0974-8490.89742 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Prabha, P. Karpagam, Thirunethiran Varalakshmi, B. Packiavathy, A. Sohna Chandra Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer |
title | Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer |
title_full | Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer |
title_fullStr | Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer |
title_full_unstemmed | Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer |
title_short | Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer |
title_sort | indigenous anti-ulcer activity of musa sapientum on peptic ulcer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249781/ https://www.ncbi.nlm.nih.gov/pubmed/22224045 http://dx.doi.org/10.4103/0974-8490.89742 |
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