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Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test
BACKGROUND: Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice. MATERIALS...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250035/ https://www.ncbi.nlm.nih.gov/pubmed/22224057 http://dx.doi.org/10.4103/0974-8490.91030 |
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author | Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Bi, Yuanyuan Fukata, Hideki Ueno, Koichi |
author_facet | Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Bi, Yuanyuan Fukata, Hideki Ueno, Koichi |
author_sort | Yamaura, Katsunori |
collection | PubMed |
description | BACKGROUND: Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice. MATERIALS AND METHODS: Mice were individually forced to swim in an open cylindrical container, one hour after oral administration of young green barley leaf (400 or 1000 mg / kg) or imipramine (100 mg / kg). Expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor, and glucocorticoid receptor in the brain was analyzed using real-time quantitative polymerase chain reaction (PCR). RESULTS: There was a significant antidepressant-like effect in the forced swimming test; both 400 and 1000 mg / kg young green barley leaves, as well as the positive control imipramine (100 mg / kg), reduced the immobility duration compared to the vehicle group. The expression of mRNA for NGF detected in the hippocampus immediately after the last swimming test was higher than that in the non-swimming group (Nil). Oral administration of imipramine suppressed this increase to the level of the Nil group. Young green barley leaf (400 and 1000 mg / kg) also showed a moderate decrease in the expression of mRNA for NGF, in a dose-dependent manner. CONCLUSION: Oral administration of young green barley leaf is able to produce an antidepressant-like effect in the forced swimming test. Consequently it is possible that the antidepressant-like effects of the young green barley leaf are, at least in part, mediated by an inhibition of the increase in the hippocampus levels of NGF. |
format | Online Article Text |
id | pubmed-3250035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32500352012-01-05 Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Bi, Yuanyuan Fukata, Hideki Ueno, Koichi Pharmacognosy Res Original Article BACKGROUND: Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice. MATERIALS AND METHODS: Mice were individually forced to swim in an open cylindrical container, one hour after oral administration of young green barley leaf (400 or 1000 mg / kg) or imipramine (100 mg / kg). Expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor, and glucocorticoid receptor in the brain was analyzed using real-time quantitative polymerase chain reaction (PCR). RESULTS: There was a significant antidepressant-like effect in the forced swimming test; both 400 and 1000 mg / kg young green barley leaves, as well as the positive control imipramine (100 mg / kg), reduced the immobility duration compared to the vehicle group. The expression of mRNA for NGF detected in the hippocampus immediately after the last swimming test was higher than that in the non-swimming group (Nil). Oral administration of imipramine suppressed this increase to the level of the Nil group. Young green barley leaf (400 and 1000 mg / kg) also showed a moderate decrease in the expression of mRNA for NGF, in a dose-dependent manner. CONCLUSION: Oral administration of young green barley leaf is able to produce an antidepressant-like effect in the forced swimming test. Consequently it is possible that the antidepressant-like effects of the young green barley leaf are, at least in part, mediated by an inhibition of the increase in the hippocampus levels of NGF. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3250035/ /pubmed/22224057 http://dx.doi.org/10.4103/0974-8490.91030 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Bi, Yuanyuan Fukata, Hideki Ueno, Koichi Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test |
title | Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test |
title_full | Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test |
title_fullStr | Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test |
title_full_unstemmed | Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test |
title_short | Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test |
title_sort | antidepressant-like effects of young green barley leaf (hordeum vulgare l.) in the mouse forced swimming test |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250035/ https://www.ncbi.nlm.nih.gov/pubmed/22224057 http://dx.doi.org/10.4103/0974-8490.91030 |
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