Cargando…

Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen

PURPOSE: During stimulated in vitro fertilization (IVF) cycle, up to 30% of the recovered oocytes are immature ones which have poor fertilization capacity; however, the precise influencing factors are largely unknown. Here, we analyzed the association of oocyte immaturity with woman's age in IV...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hee Jun, Jee, Byung Chul, Suh, Chang Suk, Kim, Seok Hyun, Moon, Shin Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250345/
https://www.ncbi.nlm.nih.gov/pubmed/22187250
http://dx.doi.org/10.3349/ymj.2012.53.1.181
_version_ 1782220451488989184
author Lee, Hee Jun
Jee, Byung Chul
Suh, Chang Suk
Kim, Seok Hyun
Moon, Shin Yong
author_facet Lee, Hee Jun
Jee, Byung Chul
Suh, Chang Suk
Kim, Seok Hyun
Moon, Shin Yong
author_sort Lee, Hee Jun
collection PubMed
description PURPOSE: During stimulated in vitro fertilization (IVF) cycle, up to 30% of the recovered oocytes are immature ones which have poor fertilization capacity; however, the precise influencing factors are largely unknown. Here, we analyzed the association of oocyte immaturity with woman's age in IVF cycles stimulated by single regimen. MATERIALS AND METHODS: A total of one-hundred ninety five IVF cycles stimulated by recombinant FSH and GnRH antagonist protocol between 2003 and 2009 were analyzed retrospectively. The mean age of women was 34.2±4.0 (26-45 years). After triggering by exogenous hCG, an ultrasound-guided retrieval of oocytes was performed 35-36 hours later. All clinical data were stratified by woman's age; group I: ≤30 (n=36), II: 31-35 (n=83), III: 36-40 (n=57), and IV: ≥41 (n=19). RESULTS: The total retrieved oocytes, as well as immature oocytes, were significantly lower in group IV, however, the mean % of immature oocytes was significantly higher in group IV than other age groups. Oocyte immaturity tended to decrease as increasing age in women aged 40 years or less. CONCLUSION: In stimulated IVF cycle, much higher oocyte immaturity was noted in women aged 41 years or more.
format Online
Article
Text
id pubmed-3250345
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Yonsei University College of Medicine
record_format MEDLINE/PubMed
spelling pubmed-32503452012-01-09 Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen Lee, Hee Jun Jee, Byung Chul Suh, Chang Suk Kim, Seok Hyun Moon, Shin Yong Yonsei Med J Original Article PURPOSE: During stimulated in vitro fertilization (IVF) cycle, up to 30% of the recovered oocytes are immature ones which have poor fertilization capacity; however, the precise influencing factors are largely unknown. Here, we analyzed the association of oocyte immaturity with woman's age in IVF cycles stimulated by single regimen. MATERIALS AND METHODS: A total of one-hundred ninety five IVF cycles stimulated by recombinant FSH and GnRH antagonist protocol between 2003 and 2009 were analyzed retrospectively. The mean age of women was 34.2±4.0 (26-45 years). After triggering by exogenous hCG, an ultrasound-guided retrieval of oocytes was performed 35-36 hours later. All clinical data were stratified by woman's age; group I: ≤30 (n=36), II: 31-35 (n=83), III: 36-40 (n=57), and IV: ≥41 (n=19). RESULTS: The total retrieved oocytes, as well as immature oocytes, were significantly lower in group IV, however, the mean % of immature oocytes was significantly higher in group IV than other age groups. Oocyte immaturity tended to decrease as increasing age in women aged 40 years or less. CONCLUSION: In stimulated IVF cycle, much higher oocyte immaturity was noted in women aged 41 years or more. Yonsei University College of Medicine 2012-01-01 2011-11-30 /pmc/articles/PMC3250345/ /pubmed/22187250 http://dx.doi.org/10.3349/ymj.2012.53.1.181 Text en © Copyright: Yonsei University College of Medicine 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Hee Jun
Jee, Byung Chul
Suh, Chang Suk
Kim, Seok Hyun
Moon, Shin Yong
Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen
title Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen
title_full Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen
title_fullStr Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen
title_full_unstemmed Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen
title_short Oocyte Maturity in Relation to Woman's Age in In Vitro Fertilization Cycles Stimulated by Single Regimen
title_sort oocyte maturity in relation to woman's age in in vitro fertilization cycles stimulated by single regimen
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250345/
https://www.ncbi.nlm.nih.gov/pubmed/22187250
http://dx.doi.org/10.3349/ymj.2012.53.1.181
work_keys_str_mv AT leeheejun oocytematurityinrelationtowomansageininvitrofertilizationcyclesstimulatedbysingleregimen
AT jeebyungchul oocytematurityinrelationtowomansageininvitrofertilizationcyclesstimulatedbysingleregimen
AT suhchangsuk oocytematurityinrelationtowomansageininvitrofertilizationcyclesstimulatedbysingleregimen
AT kimseokhyun oocytematurityinrelationtowomansageininvitrofertilizationcyclesstimulatedbysingleregimen
AT moonshinyong oocytematurityinrelationtowomansageininvitrofertilizationcyclesstimulatedbysingleregimen