Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels

PURPOSE: Unoprostone isopropyl (unoprostone) is a docosanoid currently used as an antiglaucoma agent. Unoprostone is known to have neuroprotective effects and to activate large conductance Ca(2+)-activated K(+) (BK) channels. Recently, unoprostone has been tested in clinical studies as a therapeutic...

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Detalles Bibliográficos
Autores principales: Tsuruma, Kazuhiro, Tanaka, Yuka, Shimazawa, Masamitsu, Mashima, Yukihiko, Hara, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250378/
https://www.ncbi.nlm.nih.gov/pubmed/22219651

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