Deep Evolutionary Conservation of an Intramolecular Protein Kinase Activation Mechanism

DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases. DYRKs have been characterized in organisms from yeast to human; however,...

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Detalles Bibliográficos
Autores principales: Han, Jingfen, Miranda-Saavedra, Diego, Luebbering, Nathan, Singh, Aman, Sibbet, Gary, Ferguson, Michael A. J., Cleghon, Vaughn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250476/
https://www.ncbi.nlm.nih.gov/pubmed/22235329
http://dx.doi.org/10.1371/journal.pone.0029702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250476/
https://www.ncbi.nlm.nih.gov/pubmed/22235329
http://dx.doi.org/10.1371/journal.pone.0029702

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