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Glucose-Induced O(2) Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

BACKGROUND: Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-dependent manner. METHODOLOGY/PRINCIPAL FINDINGS: Isol...

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Detalles Bibliográficos
Autores principales:	Bensellam, Mohammed, Duvillié, Bertrand, Rybachuk, Galyna, Laybutt, D. Ross, Magnan, Christophe, Guiot, Yves, Pouysségur, Jacques, Jonas, Jean-Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250482/ https://www.ncbi.nlm.nih.gov/pubmed/22235342 http://dx.doi.org/10.1371/journal.pone.0029807

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