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Age-dependent alteration of TGF-β signalling in osteoarthritis

Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-β has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced...

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Detalles Bibliográficos
Autores principales:	van der Kraan, Peter M., Goumans, Marie-José, Blaney Davidson, Esmeralda, ten Dijke, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250613/ https://www.ncbi.nlm.nih.gov/pubmed/21638205 http://dx.doi.org/10.1007/s00441-011-1194-6

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