An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy

We report the case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis (ALS) associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies. This unusual association between ALS and anti-MAG antibodies has previousl...

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Autores principales: Jurici, Snejana, Laquerrière, Annie, Bedat-Millet, Anne-Laure, Jardin, Fabrice, Musset, Lucile, Vallat, Jean-Michel, Hannequin, Didier, Martinaud, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Published: December, 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250649/
https://www.ncbi.nlm.nih.gov/pubmed/22220157
http://dx.doi.org/10.1159/000335004
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author Jurici, Snejana
Laquerrière, Annie
Bedat-Millet, Anne-Laure
Jardin, Fabrice
Musset, Lucile
Vallat, Jean-Michel
Hannequin, Didier
Martinaud, Olivier
author_facet Jurici, Snejana
Laquerrière, Annie
Bedat-Millet, Anne-Laure
Jardin, Fabrice
Musset, Lucile
Vallat, Jean-Michel
Hannequin, Didier
Martinaud, Olivier
author_sort Jurici, Snejana
collection PubMed
description We report the case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis (ALS) associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies. This unusual association between ALS and anti-MAG antibodies has previously been reported in a single case. Our present case, at neuropathological examination, demonstrated no causative link between anti-MAG antibodies and ALS.
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spelling pubmed-32506492012-01-04 An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy Jurici, Snejana Laquerrière, Annie Bedat-Millet, Anne-Laure Jardin, Fabrice Musset, Lucile Vallat, Jean-Michel Hannequin, Didier Martinaud, Olivier Case Rep Neurol Published: December, 2011 We report the case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis (ALS) associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies. This unusual association between ALS and anti-MAG antibodies has previously been reported in a single case. Our present case, at neuropathological examination, demonstrated no causative link between anti-MAG antibodies and ALS. S. Karger AG 2011-12-05 /pmc/articles/PMC3250649/ /pubmed/22220157 http://dx.doi.org/10.1159/000335004 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: December, 2011
Jurici, Snejana
Laquerrière, Annie
Bedat-Millet, Anne-Laure
Jardin, Fabrice
Musset, Lucile
Vallat, Jean-Michel
Hannequin, Didier
Martinaud, Olivier
An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy
title An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy
title_full An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy
title_fullStr An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy
title_full_unstemmed An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy
title_short An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy
title_sort autopsy case of amyotrophic lateral sclerosis with waldenström macroglobulinemia and anti-mag gammopathy
topic Published: December, 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250649/
https://www.ncbi.nlm.nih.gov/pubmed/22220157
http://dx.doi.org/10.1159/000335004
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