β(2)-adrenoceptor blockage induces G(1)/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

BACKGROUND: Smoking and stress, pancreatic cancer (PanCa) risk factors, stimulate nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and catecholamines production respectively. NNK and catecholamine bind the β-adrenoceptors and induce PanCa cell proliferation; and we have previously su...

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Detalles Bibliográficos
Autores principales: Zhang, Dong, Ma, Qingyong, Wang, Zheng, Zhang, Min, Guo, Kun, Wang, Fengfei, Wu, Erxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250953/
https://www.ncbi.nlm.nih.gov/pubmed/22118662
http://dx.doi.org/10.1186/1476-4598-10-146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250953/
https://www.ncbi.nlm.nih.gov/pubmed/22118662
http://dx.doi.org/10.1186/1476-4598-10-146

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