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Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

BACKGROUND: The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrect...

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Autores principales: Henze, Andrea, Raila, Jens, Kempf, Caroline, Reinke, Petra, Sefrin, Anett, Querfeld, Uwe, Schweigert, Florian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250968/
https://www.ncbi.nlm.nih.gov/pubmed/22151790
http://dx.doi.org/10.1186/1476-511X-10-231
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author Henze, Andrea
Raila, Jens
Kempf, Caroline
Reinke, Petra
Sefrin, Anett
Querfeld, Uwe
Schweigert, Florian J
author_facet Henze, Andrea
Raila, Jens
Kempf, Caroline
Reinke, Petra
Sefrin, Anett
Querfeld, Uwe
Schweigert, Florian J
author_sort Henze, Andrea
collection PubMed
description BACKGROUND: The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT. RESULTS: As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months. CONCLUSION: LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
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spelling pubmed-32509682012-01-05 Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study Henze, Andrea Raila, Jens Kempf, Caroline Reinke, Petra Sefrin, Anett Querfeld, Uwe Schweigert, Florian J Lipids Health Dis Research BACKGROUND: The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT. RESULTS: As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months. CONCLUSION: LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors. BioMed Central 2011-12-07 /pmc/articles/PMC3250968/ /pubmed/22151790 http://dx.doi.org/10.1186/1476-511X-10-231 Text en Copyright ©2011 Henze et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Henze, Andrea
Raila, Jens
Kempf, Caroline
Reinke, Petra
Sefrin, Anett
Querfeld, Uwe
Schweigert, Florian J
Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study
title Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study
title_full Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study
title_fullStr Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study
title_full_unstemmed Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study
title_short Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study
title_sort vitamin a metabolism is changed in donors after living-kidney transplantation: an observational study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250968/
https://www.ncbi.nlm.nih.gov/pubmed/22151790
http://dx.doi.org/10.1186/1476-511X-10-231
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