Cargando…

Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study

Malaria remains endemic in tropical areas, especially in Africa. For the evaluation of new tools and to further our understanding of host-parasite interactions, knowing the environmental risk of transmission—even at a very local scale—is essential. The aim of this study was to assess how malaria tra...

Descripción completa

Detalles Bibliográficos
Autores principales: Cottrell, Gilles, Kouwaye, Bienvenue, Pierrat, Charlotte, le Port, Agnès, Bouraïma, Aziz, Fonton, Noël, Hounkonnou, Mahouton Norbert, Massougbodji, Achille, Corbel, Vincent, Garcia, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251550/
https://www.ncbi.nlm.nih.gov/pubmed/22238582
http://dx.doi.org/10.1371/journal.pone.0028812
_version_ 1782220535167451136
author Cottrell, Gilles
Kouwaye, Bienvenue
Pierrat, Charlotte
le Port, Agnès
Bouraïma, Aziz
Fonton, Noël
Hounkonnou, Mahouton Norbert
Massougbodji, Achille
Corbel, Vincent
Garcia, André
author_facet Cottrell, Gilles
Kouwaye, Bienvenue
Pierrat, Charlotte
le Port, Agnès
Bouraïma, Aziz
Fonton, Noël
Hounkonnou, Mahouton Norbert
Massougbodji, Achille
Corbel, Vincent
Garcia, André
author_sort Cottrell, Gilles
collection PubMed
description Malaria remains endemic in tropical areas, especially in Africa. For the evaluation of new tools and to further our understanding of host-parasite interactions, knowing the environmental risk of transmission—even at a very local scale—is essential. The aim of this study was to assess how malaria transmission is influenced and can be predicted by local climatic and environmental factors. As the entomological part of a cohort study of 650 newborn babies in nine villages in the Tori Bossito district of Southern Benin between June 2007 and February 2010, human landing catches were performed to assess the density of malaria vectors and transmission intensity. Climatic factors as well as household characteristics were recorded throughout the study. Statistical correlations between Anopheles density and environmental and climatic factors were tested using a three-level Poisson mixed regression model. The results showed both temporal variations in vector density (related to season and rainfall), and spatial variations at the level of both village and house. These spatial variations could be largely explained by factors associated with the house's immediate surroundings, namely soil type, vegetation index and the proximity of a watercourse. Based on these results, a predictive regression model was developed using a leave-one-out method, to predict the spatiotemporal variability of malaria transmission in the nine villages. This study points up the importance of local environmental factors in malaria transmission and describes a model to predict the transmission risk of individual children, based on environmental and behavioral characteristics.
format Online
Article
Text
id pubmed-3251550
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-32515502012-01-11 Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study Cottrell, Gilles Kouwaye, Bienvenue Pierrat, Charlotte le Port, Agnès Bouraïma, Aziz Fonton, Noël Hounkonnou, Mahouton Norbert Massougbodji, Achille Corbel, Vincent Garcia, André PLoS One Research Article Malaria remains endemic in tropical areas, especially in Africa. For the evaluation of new tools and to further our understanding of host-parasite interactions, knowing the environmental risk of transmission—even at a very local scale—is essential. The aim of this study was to assess how malaria transmission is influenced and can be predicted by local climatic and environmental factors. As the entomological part of a cohort study of 650 newborn babies in nine villages in the Tori Bossito district of Southern Benin between June 2007 and February 2010, human landing catches were performed to assess the density of malaria vectors and transmission intensity. Climatic factors as well as household characteristics were recorded throughout the study. Statistical correlations between Anopheles density and environmental and climatic factors were tested using a three-level Poisson mixed regression model. The results showed both temporal variations in vector density (related to season and rainfall), and spatial variations at the level of both village and house. These spatial variations could be largely explained by factors associated with the house's immediate surroundings, namely soil type, vegetation index and the proximity of a watercourse. Based on these results, a predictive regression model was developed using a leave-one-out method, to predict the spatiotemporal variability of malaria transmission in the nine villages. This study points up the importance of local environmental factors in malaria transmission and describes a model to predict the transmission risk of individual children, based on environmental and behavioral characteristics. Public Library of Science 2012-01-04 /pmc/articles/PMC3251550/ /pubmed/22238582 http://dx.doi.org/10.1371/journal.pone.0028812 Text en Cottrell et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cottrell, Gilles
Kouwaye, Bienvenue
Pierrat, Charlotte
le Port, Agnès
Bouraïma, Aziz
Fonton, Noël
Hounkonnou, Mahouton Norbert
Massougbodji, Achille
Corbel, Vincent
Garcia, André
Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study
title Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study
title_full Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study
title_fullStr Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study
title_full_unstemmed Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study
title_short Modeling the Influence of Local Environmental Factors on Malaria Transmission in Benin and Its Implications for Cohort Study
title_sort modeling the influence of local environmental factors on malaria transmission in benin and its implications for cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251550/
https://www.ncbi.nlm.nih.gov/pubmed/22238582
http://dx.doi.org/10.1371/journal.pone.0028812
work_keys_str_mv AT cottrellgilles modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT kouwayebienvenue modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT pierratcharlotte modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT leportagnes modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT bouraimaaziz modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT fontonnoel modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT hounkonnoumahoutonnorbert modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT massougbodjiachille modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT corbelvincent modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy
AT garciaandre modelingtheinfluenceoflocalenvironmentalfactorsonmalariatransmissioninbeninanditsimplicationsforcohortstudy