Effect of P to A Mutation of the N-Terminal Residue Adjacent to the Rgd Motif on Rhodostomin: Importance of Dynamics in Integrin Recognition

Rhodostomin (Rho) is an RGD protein that specifically inhibits integrins. We found that Rho mutants with the P48A mutation 4.4–11.5 times more actively inhibited integrin α5β1. Structural analysis showed that they have a similar 3D conformation for the RGD loop. Docking analysis also showed no diffe...

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Detalles Bibliográficos
Autores principales: Shiu, Jia-Hau, Chen, Chiu-Yueh, Chen, Yi-Chun, Chang, Yao-Tsung, Chang, Yung-Sheng, Huang, Chun-Hao, Chuang, Woei-Jer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251565/
https://www.ncbi.nlm.nih.gov/pubmed/22238583
http://dx.doi.org/10.1371/journal.pone.0028833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251565/
https://www.ncbi.nlm.nih.gov/pubmed/22238583
http://dx.doi.org/10.1371/journal.pone.0028833

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