Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice

BACKGROUND: Metallothionein-I and -II (MT-I/II) is produced by reactive astrocytes in the injured brain and has been shown to have neuroprotective effects. The neuroprotective effects of MT-I/II can be replicated in vitro which suggests that MT-I/II may act directly on injured neurons. However, MT-I...

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Detalles Bibliográficos
Autores principales: Pankhurst, Michael W, Bennett, William, Kirkcaldie, Matthew TK, West, Adrian K, Chung, Roger S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251619/
https://www.ncbi.nlm.nih.gov/pubmed/22152221
http://dx.doi.org/10.1186/1742-2094-8-172

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