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Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration

Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal an...

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Autores principales: Chen, Eric Y., Daley, David, Wang, Yung-Chen, Garnica, Maria, Chen, Chi-Shuo, Chin, Wei-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251626/
https://www.ncbi.nlm.nih.gov/pubmed/22355725
http://dx.doi.org/10.1038/srep00211
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author Chen, Eric Y.
Daley, David
Wang, Yung-Chen
Garnica, Maria
Chen, Chi-Shuo
Chin, Wei-Chun
author_facet Chen, Eric Y.
Daley, David
Wang, Yung-Chen
Garnica, Maria
Chen, Chi-Shuo
Chin, Wei-Chun
author_sort Chen, Eric Y.
collection PubMed
description Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal and digestive disorders. Applications of current mucolytics may yield short-term improvements but are continuously challenged by undesirable side-effects. While nanoparticles (NPs) can interact with mucin polymers, whether functionalized NPs can rectify mucus rheology is unknown. Herein, we report that carboxyl-functionalized NPs (24 nm and 120 nm) dramatically reduced mucin gel size and accelerated mucin matrix hydration rate (diffusivity). Our results suggest that carboxyl-functionalized NPs disperse mucin gels possibly by enhancing network hydration. This report highlights the prospective usages of carboxyl-functionalized NPs as a novel mucus dispersant or mucolytic agent in adjusting mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of patients suffering from relevant diseases.
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spelling pubmed-32516262012-01-10 Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration Chen, Eric Y. Daley, David Wang, Yung-Chen Garnica, Maria Chen, Chi-Shuo Chin, Wei-Chun Sci Rep Article Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal and digestive disorders. Applications of current mucolytics may yield short-term improvements but are continuously challenged by undesirable side-effects. While nanoparticles (NPs) can interact with mucin polymers, whether functionalized NPs can rectify mucus rheology is unknown. Herein, we report that carboxyl-functionalized NPs (24 nm and 120 nm) dramatically reduced mucin gel size and accelerated mucin matrix hydration rate (diffusivity). Our results suggest that carboxyl-functionalized NPs disperse mucin gels possibly by enhancing network hydration. This report highlights the prospective usages of carboxyl-functionalized NPs as a novel mucus dispersant or mucolytic agent in adjusting mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of patients suffering from relevant diseases. Nature Publishing Group 2012-01-05 /pmc/articles/PMC3251626/ /pubmed/22355725 http://dx.doi.org/10.1038/srep00211 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Chen, Eric Y.
Daley, David
Wang, Yung-Chen
Garnica, Maria
Chen, Chi-Shuo
Chin, Wei-Chun
Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
title Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
title_full Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
title_fullStr Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
title_full_unstemmed Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
title_short Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
title_sort functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251626/
https://www.ncbi.nlm.nih.gov/pubmed/22355725
http://dx.doi.org/10.1038/srep00211
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