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Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration
Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251626/ https://www.ncbi.nlm.nih.gov/pubmed/22355725 http://dx.doi.org/10.1038/srep00211 |
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author | Chen, Eric Y. Daley, David Wang, Yung-Chen Garnica, Maria Chen, Chi-Shuo Chin, Wei-Chun |
author_facet | Chen, Eric Y. Daley, David Wang, Yung-Chen Garnica, Maria Chen, Chi-Shuo Chin, Wei-Chun |
author_sort | Chen, Eric Y. |
collection | PubMed |
description | Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal and digestive disorders. Applications of current mucolytics may yield short-term improvements but are continuously challenged by undesirable side-effects. While nanoparticles (NPs) can interact with mucin polymers, whether functionalized NPs can rectify mucus rheology is unknown. Herein, we report that carboxyl-functionalized NPs (24 nm and 120 nm) dramatically reduced mucin gel size and accelerated mucin matrix hydration rate (diffusivity). Our results suggest that carboxyl-functionalized NPs disperse mucin gels possibly by enhancing network hydration. This report highlights the prospective usages of carboxyl-functionalized NPs as a novel mucus dispersant or mucolytic agent in adjusting mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of patients suffering from relevant diseases. |
format | Online Article Text |
id | pubmed-3251626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-32516262012-01-10 Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration Chen, Eric Y. Daley, David Wang, Yung-Chen Garnica, Maria Chen, Chi-Shuo Chin, Wei-Chun Sci Rep Article Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance. These symptoms are some of the cardinal clinical manifestations found throughout major respiratory diseases as well as gastrointestinal and digestive disorders. Applications of current mucolytics may yield short-term improvements but are continuously challenged by undesirable side-effects. While nanoparticles (NPs) can interact with mucin polymers, whether functionalized NPs can rectify mucus rheology is unknown. Herein, we report that carboxyl-functionalized NPs (24 nm and 120 nm) dramatically reduced mucin gel size and accelerated mucin matrix hydration rate (diffusivity). Our results suggest that carboxyl-functionalized NPs disperse mucin gels possibly by enhancing network hydration. This report highlights the prospective usages of carboxyl-functionalized NPs as a novel mucus dispersant or mucolytic agent in adjusting mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of patients suffering from relevant diseases. Nature Publishing Group 2012-01-05 /pmc/articles/PMC3251626/ /pubmed/22355725 http://dx.doi.org/10.1038/srep00211 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Chen, Eric Y. Daley, David Wang, Yung-Chen Garnica, Maria Chen, Chi-Shuo Chin, Wei-Chun Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
title | Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
title_full | Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
title_fullStr | Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
title_full_unstemmed | Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
title_short | Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
title_sort | functionalized carboxyl nanoparticles enhance mucus dispersion and hydration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251626/ https://www.ncbi.nlm.nih.gov/pubmed/22355725 http://dx.doi.org/10.1038/srep00211 |
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