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Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor

Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda asparagoides water...

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Autores principales: Endale, Mehari, Song, Jae Chan, Rhee, Man Hee, Liu, Kwang-Hyeon, Kim, Taek-Kyum, Kwon, Joong Goo, Park, Kyung Sik, Chung, Ki-Myung, Kim, Tae Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251762/
https://www.ncbi.nlm.nih.gov/pubmed/22232640
http://dx.doi.org/10.5625/lar.2011.27.4.317
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author Endale, Mehari
Song, Jae Chan
Rhee, Man Hee
Liu, Kwang-Hyeon
Kim, Taek-Kyum
Kwon, Joong Goo
Park, Kyung Sik
Chung, Ki-Myung
Kim, Tae Wan
author_facet Endale, Mehari
Song, Jae Chan
Rhee, Man Hee
Liu, Kwang-Hyeon
Kim, Taek-Kyum
Kwon, Joong Goo
Park, Kyung Sik
Chung, Ki-Myung
Kim, Tae Wan
author_sort Endale, Mehari
collection PubMed
description Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda asparagoides water fraction of the extract (SAWF) on antral motility in vitro. Muscle strips from rat gastric antrum were set up in an organ bath in a circular orientation. SAWF (100 µg/mL) inhibited the spontaneous contraction of antral circular muscle strips. These inhibitory effects were not significantly affected by tetrodotoxin (1 µM), N(ω)-Nitro-L-arginine methyl ester hydrochloride (100 µM), 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (10 µM), ryanodine (10 µM) and phentolamine (10 µM). SAWF-induced inhibition was mostly restored by cyclopiazonic acid (10 µM). Furthermore, the β-adrenergic receptor antagonist, propranolol (10 µM), abolished SAWF-induced inhibition. These results suggest that SAWF may exert its activity on gastrointestinal smooth muscle via â-adrenergic receptors and sarcoplasmic reticulum Ca(2+) ATPase.
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spelling pubmed-32517622012-01-09 Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor Endale, Mehari Song, Jae Chan Rhee, Man Hee Liu, Kwang-Hyeon Kim, Taek-Kyum Kwon, Joong Goo Park, Kyung Sik Chung, Ki-Myung Kim, Tae Wan Lab Anim Res Original Article Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda asparagoides water fraction of the extract (SAWF) on antral motility in vitro. Muscle strips from rat gastric antrum were set up in an organ bath in a circular orientation. SAWF (100 µg/mL) inhibited the spontaneous contraction of antral circular muscle strips. These inhibitory effects were not significantly affected by tetrodotoxin (1 µM), N(ω)-Nitro-L-arginine methyl ester hydrochloride (100 µM), 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (10 µM), ryanodine (10 µM) and phentolamine (10 µM). SAWF-induced inhibition was mostly restored by cyclopiazonic acid (10 µM). Furthermore, the β-adrenergic receptor antagonist, propranolol (10 µM), abolished SAWF-induced inhibition. These results suggest that SAWF may exert its activity on gastrointestinal smooth muscle via â-adrenergic receptors and sarcoplasmic reticulum Ca(2+) ATPase. Korean Association for Laboratory Animal Science 2011-12 2011-12-19 /pmc/articles/PMC3251762/ /pubmed/22232640 http://dx.doi.org/10.5625/lar.2011.27.4.317 Text en Copyright © 2011 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Endale, Mehari
Song, Jae Chan
Rhee, Man Hee
Liu, Kwang-Hyeon
Kim, Taek-Kyum
Kwon, Joong Goo
Park, Kyung Sik
Chung, Ki-Myung
Kim, Tae Wan
Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
title Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
title_full Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
title_fullStr Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
title_full_unstemmed Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
title_short Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
title_sort inhibitory effect of suaeda asparagoides (miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251762/
https://www.ncbi.nlm.nih.gov/pubmed/22232640
http://dx.doi.org/10.5625/lar.2011.27.4.317
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