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Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease
Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link betw...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Current Science Inc.
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251783/ https://www.ncbi.nlm.nih.gov/pubmed/22247785 http://dx.doi.org/10.1007/s12170-011-0214-0 |
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author | Houben, A. J. Eringa, E. C. Jonk, A. M. Serne, E. H. Smulders, Y. M. Stehouwer, C. D. |
author_facet | Houben, A. J. Eringa, E. C. Jonk, A. M. Serne, E. H. Smulders, Y. M. Stehouwer, C. D. |
author_sort | Houben, A. J. |
collection | PubMed |
description | Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link between insulin resistance and hypertension in obesity. Many studies have shown that adipose tissue-derived substances (adipokines) interact with (micro)vascular function and influence insulin sensitivity. In the past, research focused on adipokines from perivascular adipose tissue (PVAT). In this review, we focus on the interactions between adipokines, predominantly from PVAT, and microvascular function in relation to the development of insulin resistance, diabetes, and cardiovascular disease. |
format | Online Article Text |
id | pubmed-3251783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Current Science Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-32517832012-01-11 Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease Houben, A. J. Eringa, E. C. Jonk, A. M. Serne, E. H. Smulders, Y. M. Stehouwer, C. D. Curr Cardiovasc Risk Rep Diabetes and Insulin Resistance (JB Meigs and M Rutter, Section Editors) Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link between insulin resistance and hypertension in obesity. Many studies have shown that adipose tissue-derived substances (adipokines) interact with (micro)vascular function and influence insulin sensitivity. In the past, research focused on adipokines from perivascular adipose tissue (PVAT). In this review, we focus on the interactions between adipokines, predominantly from PVAT, and microvascular function in relation to the development of insulin resistance, diabetes, and cardiovascular disease. Current Science Inc. 2011-11-22 2012 /pmc/articles/PMC3251783/ /pubmed/22247785 http://dx.doi.org/10.1007/s12170-011-0214-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Diabetes and Insulin Resistance (JB Meigs and M Rutter, Section Editors) Houben, A. J. Eringa, E. C. Jonk, A. M. Serne, E. H. Smulders, Y. M. Stehouwer, C. D. Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease |
title | Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease |
title_full | Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease |
title_fullStr | Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease |
title_full_unstemmed | Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease |
title_short | Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease |
title_sort | perivascular fat and the microcirculation: relevance to insulin resistance, diabetes, and cardiovascular disease |
topic | Diabetes and Insulin Resistance (JB Meigs and M Rutter, Section Editors) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251783/ https://www.ncbi.nlm.nih.gov/pubmed/22247785 http://dx.doi.org/10.1007/s12170-011-0214-0 |
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