Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets

The topoisomerase I (Top 1) poison irinotecan is an important component of the modern treatment of colorectal cancer. By stabilising Top 1-DNA complexes, irinotecan generates Top 1-linked DNA single-strand breaks that can evolve into double-strand breaks and ultimately cause cell death. However, can...

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Detalles Bibliográficos
Autores principales: Gilbert, D C, Chalmers, A J, El-Khamisy, S F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251848/
https://www.ncbi.nlm.nih.gov/pubmed/22108516
http://dx.doi.org/10.1038/bjc.2011.498

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