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Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk
BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of t...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251877/ https://www.ncbi.nlm.nih.gov/pubmed/22033276 http://dx.doi.org/10.1038/bjc.2011.448 |
| _version_ | 1782220575176916992 |
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| author | Stevens, K N Garcia-Closas, M Fredericksen, Z Kosel, M Pankratz, V S Hopper, J L Dite, G S Apicella, C Southey, M C Schmidt, M K Broeks, A Van ‘t Veer, L J Tollenaar, R A E M Fasching, P A Beckmann, M W Hein, A Ekici, A B Johnson, N Peto, J dos Santos Silva, I Gibson, L Sawyer, E Tomlinson, I Kerin, M J Chanock, S Lissowska, J Hunter, D J Hoover, R N Thomas, G D Milne, R L Pérez, JI Arias González-Neira, A Benítez, J Burwinkel, B Meindl, A Schmutzler, R K Bartrar, C R Hamann, U Ko, Y D Brüning, T Chang-Claude, J Hein, R Wang-Gohrke, S Dörk, T Schürmann, P Bremer, M Hillemanns, P Bogdanova, N Zalutsky, J V Rogov, Y I Antonenkova, N Lindblom, A Margolin, S Mannermaa, A Kataja, V Kosma, V-M Hartikainen, J Chenevix-Trench, G Chen, X Peterlongo, P Bonanni, B Bernard, L Manoukian, S Wang, X Cerhan, J Vachon, C M Olson, J Giles, G G Baglietto, L McLean, C A Severi, G John, E M Miron, A Winqvist, R Pylkäs, K Jukkola-Vuorinen, A Grip, M Andrulis, I Knight, J A Glendon, G Mulligan, A M Cox, A Brock, I W Elliott, G Cross, S S Pharoah, P P Dunning, A M Pooley, K A Humphreys, M K Wang, J Kang, D Yoo, K-Y Noh, D-Y Sangrajrang, S Gabrieau, V Brennan, P McKay, J Anton-Culver, H Ziogas, A Couch, F J Easton, D F |
| author_facet | Stevens, K N Garcia-Closas, M Fredericksen, Z Kosel, M Pankratz, V S Hopper, J L Dite, G S Apicella, C Southey, M C Schmidt, M K Broeks, A Van ‘t Veer, L J Tollenaar, R A E M Fasching, P A Beckmann, M W Hein, A Ekici, A B Johnson, N Peto, J dos Santos Silva, I Gibson, L Sawyer, E Tomlinson, I Kerin, M J Chanock, S Lissowska, J Hunter, D J Hoover, R N Thomas, G D Milne, R L Pérez, JI Arias González-Neira, A Benítez, J Burwinkel, B Meindl, A Schmutzler, R K Bartrar, C R Hamann, U Ko, Y D Brüning, T Chang-Claude, J Hein, R Wang-Gohrke, S Dörk, T Schürmann, P Bremer, M Hillemanns, P Bogdanova, N Zalutsky, J V Rogov, Y I Antonenkova, N Lindblom, A Margolin, S Mannermaa, A Kataja, V Kosma, V-M Hartikainen, J Chenevix-Trench, G Chen, X Peterlongo, P Bonanni, B Bernard, L Manoukian, S Wang, X Cerhan, J Vachon, C M Olson, J Giles, G G Baglietto, L McLean, C A Severi, G John, E M Miron, A Winqvist, R Pylkäs, K Jukkola-Vuorinen, A Grip, M Andrulis, I Knight, J A Glendon, G Mulligan, A M Cox, A Brock, I W Elliott, G Cross, S S Pharoah, P P Dunning, A M Pooley, K A Humphreys, M K Wang, J Kang, D Yoo, K-Y Noh, D-Y Sangrajrang, S Gabrieau, V Brennan, P McKay, J Anton-Culver, H Ziogas, A Couch, F J Easton, D F |
| author_sort | Stevens, K N |
| collection | PubMed |
| description | BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. METHODS: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). RESULTS: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR)=0.97, 95% confidence interval (CI) 0.95–0.99, P=4.6 × 10(−3)), but did not reach significance in the BCAC replication study alone (OR=0.98, 95% CI 0.96–1.01, P=0.139). CONCLUSION: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer |
| format | Online Article Text |
| id | pubmed-3251877 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-32518772012-12-06 Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk Stevens, K N Garcia-Closas, M Fredericksen, Z Kosel, M Pankratz, V S Hopper, J L Dite, G S Apicella, C Southey, M C Schmidt, M K Broeks, A Van ‘t Veer, L J Tollenaar, R A E M Fasching, P A Beckmann, M W Hein, A Ekici, A B Johnson, N Peto, J dos Santos Silva, I Gibson, L Sawyer, E Tomlinson, I Kerin, M J Chanock, S Lissowska, J Hunter, D J Hoover, R N Thomas, G D Milne, R L Pérez, JI Arias González-Neira, A Benítez, J Burwinkel, B Meindl, A Schmutzler, R K Bartrar, C R Hamann, U Ko, Y D Brüning, T Chang-Claude, J Hein, R Wang-Gohrke, S Dörk, T Schürmann, P Bremer, M Hillemanns, P Bogdanova, N Zalutsky, J V Rogov, Y I Antonenkova, N Lindblom, A Margolin, S Mannermaa, A Kataja, V Kosma, V-M Hartikainen, J Chenevix-Trench, G Chen, X Peterlongo, P Bonanni, B Bernard, L Manoukian, S Wang, X Cerhan, J Vachon, C M Olson, J Giles, G G Baglietto, L McLean, C A Severi, G John, E M Miron, A Winqvist, R Pylkäs, K Jukkola-Vuorinen, A Grip, M Andrulis, I Knight, J A Glendon, G Mulligan, A M Cox, A Brock, I W Elliott, G Cross, S S Pharoah, P P Dunning, A M Pooley, K A Humphreys, M K Wang, J Kang, D Yoo, K-Y Noh, D-Y Sangrajrang, S Gabrieau, V Brennan, P McKay, J Anton-Culver, H Ziogas, A Couch, F J Easton, D F Br J Cancer Genetics and Genomics BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. METHODS: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). RESULTS: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR)=0.97, 95% confidence interval (CI) 0.95–0.99, P=4.6 × 10(−3)), but did not reach significance in the BCAC replication study alone (OR=0.98, 95% CI 0.96–1.01, P=0.139). CONCLUSION: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer Nature Publishing Group 2011-12-06 2011-10-27 /pmc/articles/PMC3251877/ /pubmed/22033276 http://dx.doi.org/10.1038/bjc.2011.448 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Genetics and Genomics Stevens, K N Garcia-Closas, M Fredericksen, Z Kosel, M Pankratz, V S Hopper, J L Dite, G S Apicella, C Southey, M C Schmidt, M K Broeks, A Van ‘t Veer, L J Tollenaar, R A E M Fasching, P A Beckmann, M W Hein, A Ekici, A B Johnson, N Peto, J dos Santos Silva, I Gibson, L Sawyer, E Tomlinson, I Kerin, M J Chanock, S Lissowska, J Hunter, D J Hoover, R N Thomas, G D Milne, R L Pérez, JI Arias González-Neira, A Benítez, J Burwinkel, B Meindl, A Schmutzler, R K Bartrar, C R Hamann, U Ko, Y D Brüning, T Chang-Claude, J Hein, R Wang-Gohrke, S Dörk, T Schürmann, P Bremer, M Hillemanns, P Bogdanova, N Zalutsky, J V Rogov, Y I Antonenkova, N Lindblom, A Margolin, S Mannermaa, A Kataja, V Kosma, V-M Hartikainen, J Chenevix-Trench, G Chen, X Peterlongo, P Bonanni, B Bernard, L Manoukian, S Wang, X Cerhan, J Vachon, C M Olson, J Giles, G G Baglietto, L McLean, C A Severi, G John, E M Miron, A Winqvist, R Pylkäs, K Jukkola-Vuorinen, A Grip, M Andrulis, I Knight, J A Glendon, G Mulligan, A M Cox, A Brock, I W Elliott, G Cross, S S Pharoah, P P Dunning, A M Pooley, K A Humphreys, M K Wang, J Kang, D Yoo, K-Y Noh, D-Y Sangrajrang, S Gabrieau, V Brennan, P McKay, J Anton-Culver, H Ziogas, A Couch, F J Easton, D F Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| title | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| title_full | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| title_fullStr | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| title_full_unstemmed | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| title_short | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| title_sort | evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| topic | Genetics and Genomics |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251877/ https://www.ncbi.nlm.nih.gov/pubmed/22033276 http://dx.doi.org/10.1038/bjc.2011.448 |
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