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E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is a fundamental process governing not only morphogenesis in multicellular organisms, but also cancer progression. During EMT, epithelial cadherin (E-cadherin) is downregulated while neural cadherin (N-cadherin) is upregulated, referred to as ‘c...

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Detalles Bibliográficos
Autores principales:	Araki, K, Shimura, T, Suzuki, H, Tsutsumi, S, Wada, W, Yajima, T, Kobayahi, T, Kubo, N, Kuwano, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251878/ https://www.ncbi.nlm.nih.gov/pubmed/22068819 http://dx.doi.org/10.1038/bjc.2011.452

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